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Allostery in Its Many Disguises: From Theory to Applications

  1. Author:
    Wodak, Shoshana J.
    Paci, Emanuele
    Dokholyan, Nikolay
    Berezovsky, Igor N.
    Horovitz, Amnon
    Li, Jing
    Hilser, Vincent J.
    Behar, Ivet
    Karanicolas, John
    Stock, Gerhard
    Hamm, Peter
    Stote, Roland H.
    Eberhardt, Jerome
    Chebaro, Yassmine
    Dejaegere, Annick
    Cecchini, Marco
    Changeux, Jean-Pierre
    Bolhuis, Peter G.
    Vreede, Jocelyne
    Faccioli, Pietro
    Orioli, Simone
    Ravasio, Riccardo
    Yen, Le
    Brito, Carolina
    Wyart, Matthieu
    Gkeka, Paraskevi
    Rivalta, Ivan
    Palermo, Giulia
    Mccammon, J. Andrew
    Panecka-Hofman, Joanna
    Wade, Rebecca C.
    Di Pizio, Antonella
    Niv, Masha Y.
    Nussinov,Ruth
    Tsai,Chung-Jung
    Jang,Hyunbum
    Padhorny, Dzmitry
    Kozakov, Dima
    Mcleish, Tom

  2. Author Address

    VIB VUB Ctr Struct Biol, Brussels, Belgium.Univ Leeds, Astbury Ctr, Leeds, W Yorkshire, England.Univ North Carolina Chapel Hill, Dept Biochem & Biophys, Chapel Hill, NC USA.Natl Univ Singapore, Bioinformat Inst BII, A STAR, Singapore, Singapore.Natl Univ Singapore, Dept Biol Sci, Singapore, Singapore.Weizmann Inst Sci, Dept Struct Biol, Rehovot, Israel.Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA.Johns Hopkins Univ, TC Jenkins Dept Biophys, Baltimore, MD USA.Univ Pittsburgh, Sch Med, Pittsburgh, PA USA.Fox Chase Canc Ctr, 7701 Burholme Ave, Philadelphia, PA 19111 USA.Albert Ludwigs Univ, Inst Phys, Biomol Dynam, Freiburg, Germany.Univ Zurich, Dept Chem, Zurich, Switzerland.IGBMC, Dept Integrat Struct Biol, Illkirch Graffenstaden, France.CNRS, UMR 7177, Inst Chim Strasbourg, Strasbourg, France.Univ Strasbourg, Strasbourg, France.Inst Pasteur, Paris, France.Coll France, Paris, France.Univ Amsterdam, vant Hoff Inst Mol Sci HIMS, Amsterdam, Netherlands.Univ Trento, Phys Dept, Trento, Italy.Ist Nazl Fis Nucl, TIFPA, Trento, Italy.Ecole Polytech Fed Lausanne, Inst Phys, Lausanne, Switzerland.Univ Calif Santa Barbara, Kavli Inst Theoret Phys, Santa Barbara, CA 93106 USA.Univ Fed Rio Grande do Sul, Inst Fis, BR-91501970 Porto Alegre, RS, Brazil.Sanofi R&D, Struct Design & Informat, Chilly Mazarin, France.Univ Claude Bernard Lyon 1, Univ Lyon, Ecole Normale Super Lyon, CNRS, Lyon, France.Univ Calif San Diego, Dept Chem & Biochem, San Diego, CA 92103 USA.Univ Warsaw, Fac Phys, Inst Expt Phys, Div Biophys, Warsaw, Poland.Heidelberg Univ, Heidelberg Inst Theoret Studies, Mol & Cellular Modeling Grp, Heidelberg, Germany.Heidelberg Univ, Ctr Mol Biol ZMBH, DKFZ ZMBH Alliance, Heidelberg, Germany.Tech Univ Munich, Leibniz Inst Food Syst Biol, Munich, Germany.Hebrew Univ Jerusalem, Robert H Smith Fac Agr Food & Environm, Inst Biochem Food Sci & Nutr, Jerusalem, Israel.NCI, Frederick Natl Lab Canc Res, Frederick, MD 21701 USA.SUNY Stony Brook, Dept Appl Math & Stat, Stony Brook, NY 11794 USA.Univ York, Dept Phys, York, N Yorkshire, England.Penn State Med Ctr, Dept Pharmacol, Hershey, PA USA.Penn State Med Ctr, Dept Biochem & Mol Biol, Hershey, PA USA.Tel Aviv Univ, Sackler Inst Mol Med, Dept Human Genet, Tel Aviv, Israel.Tel Aviv Univ, Mol Med Sackler Sch Med, Tel Aviv, Israel.Heidelberg Univ, Interdisciplinary Ctr Sci Comp IWR, Heidelberg, Germany.Univ Calif Riverside, Dept Bioengn, Riverside, CA 92507 USA.
    1. Year: 2019
    2. Date: Apr 2
    3. Epub Date: 2019 01 17
  2. Journal: Structure (London, England : 1993)
  3. CELL PRESS,
    1. 27
    2. 4
    3. Pages: 566-578
  5. Type of Article: Review
  6. ISSN: 0969-2126
  1. Abstract:

    Allosteric regulation plays an important role in many biological processes, such as signal transduction, transcriptional regulation, andmetabolism. Allostery is rooted in the fundamental physical properties of macromolecular systems, but its underlying mechanisms are still poorly understood. A collection of contributions to a recent interdisciplinary CECAM(Center Europeen de Calcul Atomique et Moleculaire) workshop is used here to provide an overview of the progress and remaining limitations in the understanding of the mechanistic foundations of allostery gained from computational and experimental analyses of real protein systems and model systems. The main conceptual frameworks instrumental in driving the field are discussed. We illustrate the role of these frameworks in illuminating molecular mechanisms and explaining cellular processes, and describe some of their promising practical applications in engineering molecular sensors and informing drug design efforts.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.str.2019.01.003
  3. PMID: 30744993
  4. View record in Web of Science®
  5. WOS: 000463163300003

Library Notes

  1. Fiscal Year: FY2018-2019
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