Skip NavigationSkip to Content
Return Return to Search Results

Laboratory mice born to wild mice have natural microbiota and model human immune responses

  1. Author:
    Rosshart, Stephan P.
    Herz, Jasmin
    Vassallo, Brian G.
    Hunter, Ashli
    Wall, Morgan K.
    Badger, Jonathan H.
    McCulloch, John A.
    Anastasakis, Dimitrios G.
    Sarshad, Aishe A.
    Leonardi, Irina
    Collins, Nicholas
    Blatter, Joshua A.
    Han, Seong-Ji
    Tamoutounour, Samira
    Potapova, Svetlana
    St Claire, Mark B. Foster
    Yuan,Wuxing
    Sen,Shurjo
    Dreier, Matthew S.
    Hild, Benedikt
    Hafner, Markus
    Wang, David
    Iliev, Iliyan D.
    Belkaid, Yasmine
    Trinchieri, Giorgio
    Rehermann, Barbara

  2. Author Address

    NIDDK, Immunol Sect, Liver Dis Branch, NIH,DHHS, Bethesda, MD 20892 USA.Univ Virginia, Ctr Brain Immunol & Glia, Dept Neurosci, Sch Med, Charlottesville, VA 22908 USA.NCI, Canc & Inflammat Program, Ctr Canc Res, NIH,DHHS, Bethesda, MD 20892 USA.NIAID, Mucosal Immunol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA.NIAMSD, Lab Muscle Stem Cells & Gene Regulat, Bethesda, MD 20892 USA.Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA.Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA.Weill Cornell Med, Jill Roberts Inst Res Inflammatory Bowel Dis, New York, NY 10021 USA.Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA.NCI, Leidos Biomed Res Inc, Microbiome & Genet Core, NIH, Bethesda, MD 20892 USA.NIDDK, Lab Anim Sci Sect, NIH, DHHS, Bethesda, MD 20892 USA.Univ Freiburg, Klin Innere Med 2, Univ Klinikum Freiburg, D-79106 Freiburg, Germany.MIT, Dept Biol, 77 Massachusetts Ave,68-132, Cambridge, MA 02139 USA.Univ Gothenburg, Dept Med Biochem & Cell Biol, Gothenburg, Sweden.
    1. Year: 2019
    2. Date: AUG 2
  2. Journal: SCIENCE
  3. AMER ASSOC ADVANCEMENT SCIENCE,
    1. 365
    2. 6452
    3. Pages: 461-+
  5. Type of Article: Article
  6. Article Number: eaaw4361
  7. ISSN: 0036-8075
  1. Abstract:

    Laboratory mouse studies are paramount for understanding basic biological phenomena but also have limitations. These include conflicting results caused by divergent microbiota and limited translational research value. To address both shortcomings, we transferred C57BL/6 embryos into wild mice, creating "wildlings." These mice have a natural microbiota and pathogens at all body sites and the tractable genetics of C57BL/6 mice. The bacterial microbiome, mycobiome, and virome of wildlings affect the immune landscape of multiple organs. Their gut microbiota outcompete laboratory microbiota and demonstrate resilience to environmental challenges. Wildlings, but not conventional laboratory mice, phenocopied human immune responses in two preclinical studies. A combined natural microbiota- and pathogen-based model may enhance the reproducibility of biomedical studies and increase the bench-to-bedside safety and success of immunological studies.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1126/science.aaw4361
  3. View record in Web of Science®
  4. WOS: 000478692000035

Library Notes

  1. Fiscal Year: FY2018-2019
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel