Skip NavigationSkip to Content
Return Return to Search Results

The NCI Transcriptional Pharmacodynamics Workbench: A Tool to Examine Dynamic Expression Profiling of Therapeutic Response in the NCI-60 Cell Line Panel

  1. Author:
    Monks, Anne
    Zhao, Yingdong
    Hose,Curtis
    Hamed, Hossein
    Krushkal, Julia
    Fang, Jianwen
    Sonkin, Dmitriy
    Palmisano, Alida
    Polley, Eric C.
    Fogli, Laura K.
    Konate, Mariam M.
    Miller, Sarah B.
    Simpson,Mel
    Voth,Andrea
    Li, Ming-Chung
    Harris,Erik
    Wu,Xiaolin
    Connelly,John
    Rapisarda,Annamaria
    Teicher,Beverly
    Simon, Richard
    Doroshow, James H.

  2. Author Address

    Frederick Natl Lab Canc Res, Mol Pharmacol Grp, Frederick, MD USA.NCI, Biometr Res Program, Div Canc Treatment & Diag, NIH, Rockville, MD USA.NCI, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA.Frederick Natl Lab Canc Res, Appl Dev Res Directorate, Frederick, MD USA.Frederick Natl Lab Canc Res, Canc Res Technol Program, Frederick, MD USA.NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
    1. Year: 2018
    2. Date: Dec 15
    3. Epub Date: 2018 10 24
  2. Journal: Cancer research
  3. AMER ASSOC CANCER RESEARCH,
    1. 78
    2. 24
    3. Pages: 6807-6817
  5. Type of Article: Article
  6. ISSN: 0008-5472
  1. Abstract:

    The intracellular effects and overall efficacies of anticancer therapies can vary significantly by tumor type. To identify patterns of drug-induced gene modulation that occur in different cancer cell types, we measured gene-expression changes across the NCI-60 cell line panel after exposure to 15 anticancer agents. The results were integrated into a combined database and set of interactive analysis tools, designated the NCI Transcriptional Pharmacodynamics Workbench (NCI TPW), that allows exploration of gene-expression modulation by molecular pathway, drug target, and association with drug sensitivity. We identified common transcriptional responses across agents and cell types and uncovered gene-expression changes associated with drug sensitivity. We also demonstrated the value of this tool for investigating clinically relevant molecular hypotheses and identifying candidate biomarkers of drug activity. The NCI TPW, publicly available at https://tpwb.nci.nih.gov, provides a comprehensive resource to facilitate understanding of tumor cell characteristics that define sensitivity to commonly used anticancer drugs.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1158/0008-5472.CAN-18-0989
  3. PMID: 30355619
  4. PMCID: PMC6295263
  5. View record in Web of Science®
  6. WOS: 000453465600011

Library Notes

  1. Fiscal Year: FY2018-2019
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel