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HIV-associated gut dysbiosis is independent of sexual practice and correlates with noncommunicable diseases

  1. Author:
    Vujkovic-Cvijin, I [ORCID]
    Sortino,Ornella
    Verheij, E
    Sklar, J
    Wit, F W [ORCID]
    Kootstra, N A
    Sellers, B
    Brenchley, J M
    Ananworanich, J [ORCID]
    Loeff, M Schim van der
    Belkaid, Y [ORCID]
    Reiss, P [ORCID]
    Sereti, I [ORCID]

  2. Author Address

    Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, 20892, USA., Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, National Cancer Institute, Bethesda, USA., HIV Pathogenesis Section, Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, 20892, USA., Amsterdam University Medical Centers, University of Amsterdam, Department of Global Health and Division of Infectious Diseases, Amsterdam Infection and Immunity Institute, Amsterdam Public Health Research Institute, and Amsterdam Institute for Global Health and Development, Amsterdam, Netherlands., Amsterdam University Medical Centers, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam, Netherlands., Trans-NIH Center for Human Immunology, Autoimmunity, and Inflammation, National Institutes of Health, Bethesda, MD, 20892, USA., Barrier Immunity Section, Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD, 20892, USA., SEARCH/Thai Red Cross AIDS Research Centre, Bangkok, Thailand., United States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA., Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, Netherlands., HIV Pathogenesis Section, Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD, 20892, USA. isereti@niaid.nih.gov.,
    1. Year: 2020
    2. Date: May 15
    3. Epub Date: 2020 05 15
  2. Journal: Nature communications
    1. 11
    2. 1
    3. Pages: 2448
  4. Type of Article: Article
  5. Article Number: 2448
  6. ISSN: 2041-1723
  1. Abstract:

    Loss of gut mucosal integrity and an aberrant gut microbiota are proposed mechanisms contributing to chronic inflammation and increased morbidity and mortality during antiretroviral-treated HIV disease. Sexual practice has recently been uncovered as a major source of microbiota variation, potentially confounding prior observations of gut microbiota alterations among persons with HIV (PWH). To overcome this and other confounding factors, we examine a well-powered subset of AGEhIV Cohort participants comprising antiretroviral-treated PWH and seronegative controls matched for age, body-mass index, sex, and sexual practice. We report significant gut microbiota differences in PWH regardless of sex and sexual practice including Gammaproteobacteria enrichment, Lachnospiraceae and Ruminococcaceae depletion, and decreased alpha diversity. Men who have sex with men (MSM) exhibit a distinct microbiota signature characterized by Prevotella enrichment and increased alpha diversity, which is linked with receptive anal intercourse in both males and females. Finally, the HIV-associated microbiota signature correlates with inflammatory markers including suPAR, nadir CD4 count, and prevalence of age-associated noncommunicable comorbidities.

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External Sources

  1. View Full Text
  2. DOI: 10.1038/s41467-020-16222-8
  3. PMID: 32415070
  4. View record in Web of Science®
  5. WOS: 000536569900046
  6. PII : 10.1038/s41467-020-16222-8

Library Notes

  1. Fiscal Year: FY2019-2020
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