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Helminth Mediated Attenuation of Systemic Inflammation and Microbial Translocation in Helminth-Diabetes Comorbidity

  1. Author:
    Rajamanickam, Anuradha
    Munisankar, Saravanan
    Menon, Pradeep A.
    Dolla, Chandrakumar
    Nutman, Thomas B.
    Babu, Subash

  2. Author Address

    Natl Inst Hlth, NIRT, Int Ctr Excellence Res, Chennai, Tamil Nadu, India.Natl Inst Res TB, Dept Epidemiol, Chennai, Tamil Nadu, India.NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA.NCI, Frederick Natl Lab Canc Res, Frederick, MD 21701 USA.
    1. Year: 2020
    2. Date: AUG 31
    3. Epub Date: 2020 08 31
  2. Journal: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
  3. FRONTIERS MEDIA SA,
    1. 10
    2. Pages: 431
  5. Type of Article: Article
  6. Article Number: 431
  7. ISSN: 2235-2988
  1. Abstract:

    Type 2 diabetes mellitus (T2DM) is characterized by heightened systemic inflammation and microbial translocation. Whether concomitant helminth infections can modulate this systemic response is unclear. We examined the presence of markers of systemic inflammation (levels of acute phase proteins) and of microbial translocation [levels of lipopolysaccharide (LPS) and its associated products] in T2DM individuals with (Ss(+)) or without (Ss(-))Strongyloides stercoralis(Ss) infection. We also analyzed these parameters at 6 months following anthelmintic treatment inSs(+)individuals.Ss(+)individuals exhibited significantly diminished levels of alpha-2 macroglobulin, C-reactive protein, haptoglobin and serum amyloid protein A1 compared toSs(-)individuals and these levels increased significantly following therapy. Similarly,Ss(+)individuals exhibited significantly diminished levels of LPS, sCD14, intestinal fatty acid binding protein, LPS binding protein and endotoxin IgG antibody and most of these levels increased significantly following therapy. Thus, helminth infection is associated with attenuation of systemic inflammation and microbial translocation in T2DM and its reversal following anthelmintic therapy.

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External Sources

  1. View Full Text
  2. DOI: 10.3389/fcimb.2020.00431
  3. PMID: 32984066
  4. PMCID: PMC7488178
  5. View record in Web of Science®
  6. WOS: 000570550600001

Library Notes

  1. Fiscal Year: FY2019-2020
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