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Distinct contributions of cathelin-related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis

  1. Author:
    Chen,Keqiang [ORCID]
    Yoshimura, Teizo
    Yao, Xiaohong
    Gong, Wanghua
    Huang, Jiaqiang
    Dzutsev,Amiran
    McCulloch, John
    O'hUigin, Colm
    Bian, Xiu-Wu
    Trinchieri,Giorgio
    Wang,Jiming

  2. Author Address

    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA., Laboratory of Cancer and Immunometabolism, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA., Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan., Institute of Pathology and Southwest Cancer Center, Third Military Medical University, Chongqing, China., Basic Research Program, Leidos Biomedical Research, Inc., Frederick, Maryland, USA., College of Life Sciences, Beijing Jiaotong University, Beijing, China.,
    1. Year: 2021
    2. Date: Mar
    3. Epub Date: 2021 Jan 19
  2. Journal: The Journal of Pathology
    1. 253
    2. 3
    3. Pages: 339-350
  4. Type of Article: Article
  5. Article Number: ARTN e5572
  6. ISSN: 0022-3417
  1. Abstract:

    The cathelin-related antimicrobial peptide CRAMP protects the mouse colon from inflammation, inflammation-associated carcinogenesis and disrupted microbiome balance, as shown in systemic Cnlp-/- mice (also known as Camp-/- mice). However, the mechanistic basis for the role and the cellular source of CRAMP in colon pathophysiology are ill defined. This study, using either epithelial or myeloid conditional Cnlp-/- mice, demonstrated that epithelial cell-derived CRAMP played a major role in supporting normal development of colon crypts, mucus production and repair of injured mucosa. On the other hand, myeloid cell-derived CRAMP potently supported colon epithelial resistance to bacterial invasion during acute inflammation with exacerbated mucosal damage and higher rate of mouse mortality. Therefore, a well concerted cooperation of epithelial- and myeloid-derived CRAMP is essential for colon mucosal homeostasis. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

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External Sources

  1. View Full Text
  2. DOI: 10.1002/path.5572
  3. PMID: 33104252
  4. View record in Web of Science®
  5. WOS: 000608713600001

Library Notes

  1. Fiscal Year: FY2020-2021
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