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Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines

  1. Author:
    Nance,Kellie
    Meier,Jordan

  2. Author Address

    NCI, Chem Biol Lab, Ctr Canc Res, NIH, Frederick, MD 21702 USA.
    1. Year: 2021
    2. Date: May 26
    3. Epub Date: 2021 04 06
  2. Journal: ACS central science
  3. AMER CHEMICAL SOC,
    1. 7
    2. 5
    3. Pages: 748-756
  5. Type of Article: Review
  6. ISSN: 2374-7943
  1. Abstract:

    The novel coronavirus SARS-CoV-2, the cause of the COVID-19 pandemic, has inspired one of the most efficient vaccine development campaigns in human history. A key aspect of COVID-19 mRNA vaccines is the use of the modified nucleobase N1-methylpseudouridine (m1 Psi) to increase their effectiveness. In this Outlook, we summarize the development and function of m1 Psi in synthetic mRNAs. By demystifying how a novel element within these medicines works, we aim to foster understanding and highlight future opportunities for chemical innovation.

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External Sources

  1. View Full Text
  2. DOI: 10.1021/acscentsci.1c00197
  3. PMID: 34075344
  4. PMCID: PMC8043204
  5. View record in Web of Science®
  6. WOS: 000657243600009

Library Notes

  1. Fiscal Year: FY2020-2021
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