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Epstein-Barr virus (EBV) hyperimmune globulin isolated from donors with high gp350 antibody titers protect humanized mice from challenge with EBV

  1. Author:
    Kim, JungHyun
    Bu, Wei
    Mine, Sohtaro
    Tariq, Zeshan
    Nguyen, Hanh
    Wang,Yanmei
    Tolman, Cynthia
    Mond, James
    Cohen, Jeffrey I.

  2. Author Address

    NIH, Med Virol Sect, Lab Infect Dis, Bethesda, MD 20892 USA.Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20740 USA.Frederick Natl Lab Canc Res, Clin Serv Program, Leidos Biomed Res, Frederick, MD 21702 USA.ADMA Biol, Boca Raton, FL 33487 USA.
    1. Year: 2021
    2. Date: Sep
    3. Epub Date: 2021 06 20
  2. Journal: VIROLOGY
  3. ACADEMIC PRESS INC ELSEVIER SCIENCE,
    1. 561
    2. Pages: 80-86
  5. Type of Article: Article
  6. ISSN: 0042-6822
  1. Abstract:

    Primary infection with Epstein-Barr virus (EBV) is associated with post-transplant lymphoproliferative disease and severe disease in patients with X-linked lymphoproliferative disease; no therapies are approved to prevent EBV infection in these patients. Hyperimmune globulin has been used to prevent some virus infections in immunocompromised persons. Here, we identified plasma donors with high titers of EBV gp350 and EBV B cell neutralizing antibodies. Pooled IgG isolated from these donors was compared to intravenous immunoglobulin (IVIG) for its ability to reduce viral load in the blood in humanized mice challenged with EBV. Mice that received EBV hyperimmune globulin had significantly reduced EBV DNA copy numbers compared to animals that received saline control; however, while animals that received EBV hyperimmune globulin had lower EBV DNA copies than those that received IVIG, the difference was not significant. Thus, while EBV hyperimmune globulin reduced viral load compared to IVIG, the effect was modest.

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External Sources

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  2. DOI: 10.1016/j.virol.2021.06.006
  3. View record in Web of Science®
  4. WOS: 000670888800010

Library Notes

  1. Fiscal Year: FY2020-2021
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