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Transient viral replication during analytical treatment interruptions in SIV infected macaques can alter the rebound-competent viral reservoir

  1. Author:
    Immonen,Taina
    Fennessey,Christine
    Lipkey,Leslie
    Thorpe, Abigail
    Del Prete,Greg
    Lifson,Jeffrey
    Davenport, Miles P.
    Keele,Brandon

  2. Author Address

    AIDS & Canc Virus Program, Frederick Natl Lab, Frederick, MD 21702 USA.Univ New South Wales, Kirby Inst Infect & Immun, Infect Analyt Program, Sydney, NSW, Australia.
    1. Year: 2021
    2. Date: Jun
  2. Journal: PLOS PATHOGENS
  3. PUBLIC LIBRARY SCIENCE,
    1. 17
    2. 6
  5. Type of Article: Article
  6. Article Number: e1009686
  7. ISSN: 1553-7366
  1. Abstract:

    Analytical treatment interruptions (ATIs) of antiretroviral therapy (ART) play a central role in evaluating the efficacy of HIV-1 treatment strategies targeting virus that persists despite ART. However, it remains unclear if ATIs alter the rebound-competent viral reservoir (RCVR), the virus population that persists during ART and from which viral recrudescence originates after ART discontinuation. To assess the impact of ATIs on the RCVR, we used a barcode sequence tagged SIV to track individual viral lineages through a series of ATIs in Rhesus macaques. We demonstrate that transient replication of individual rebounding lineages during an ATI can lead to their enrichment in the RCVR, increasing their probability of reactivating again after treatment discontinuation. These data establish that the RCVR can be altered by uncontrolled replication during ATI.

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External Sources

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  2. DOI: 10.1371/journal.ppat.1009686
  3. PMID: 34143853
  4. View record in Web of Science®
  5. WOS: 000671016800004

Library Notes

  1. Fiscal Year: FY2020-2021
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