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Lack of transgenerational effects of ionizing radiation exposure from the Chernobyl accident

  1. Author:
    Yeager,Meredith
    Machiela, Mitchell J.
    Kothiya, Prachi
    Dean,Michael
    Bodelon, Clara
    Suman, Shalabh
    Wang,Mingyi
    Mirabello, Lisa
    Nelson, Chase W.
    Zhou,Weiyin
    Palmer, Cameron
    Ballew, Bari
    Colli, Leandro M.
    Freedman, Neal D.
    Dagnall,Casey
    Hutchinson,Amy
    Vij, Vibha
    Maruvka, Yosi
    Hatch, Maureen
    Illienko, Iryna
    Belayev, Yuri
    Nakamura, Nori
    Chumak, Vadim
    Bakhanova, Elena
    Belyi, David
    Kryuchkov, Victor
    Golovanov, Ivan
    Gudzenko, Natalia
    Cahoon, Elizabeth K.
    Albert, Paul
    Drozdovitch, Vladimir
    Little, Mark P.
    Mabuchi, Kiyohiko
    Stewart, Chip
    Getz, Gad
    Bazyka, Dimitry
    de Gonzalez, Amy Berrington
    Chanock, Stephen J.

  2. Author Address

    NCI, Div Canc Epidemiol & Genet, Rockville, MD 20892 USA.Frederick Natl Lab Canc Res, Canc Genom Res Lab, Frederick, MD 21701 USA.SymbioSeg LLC, Arlington, VA 20148 USA.Acad Sinica, Biodivers Res Ctr, Taipei 11529, Taiwan.Amer Museum Nat Hist, Inst Comparat Genom, New York, NY 10024 USA.Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Med Imaging Hematol & Oncol, BR-14049900 Ribeirao Preto, SP, Brazil.Broad Inst Harvard & MIT, Cambridge, MA 02142 USA.Massachusetts Gen Hosp, Ctr Canc Res, Boston, MA 02114 USA.Natl Res Ctr Radiat Med, 53 Yu Illienka St, UA-04050 Kiev, Ukraine.Radiat Effects Res Fdn, Dept Mol Biosci, Minami Ku, 5-2 Hijiyama Pk, Hiroshima 7320815, Japan.Bumasyan Fed Med & Biophys Ctr, 46 Zhivopisnaya St, Moscow 123182, Russia.Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA.Harvard Med Sch, Boston, MA 02115 USA.
    1. Year: 2021
    2. Date: May 14
    3. Epub Date: 2021 04 22
  2. Journal: Science (New York, N.Y.)
  3. AMER ASSOC ADVANCEMENT SCIENCE,
    1. 372
    2. 6543
    3. Pages: 725-729
  5. Type of Article: Article
  6. ISSN: 0036-8075
  1. Abstract:

    Effects of radiation exposure from the Chernobyl nuclear accident remain a topic of interest. We investigated germline de novo mutations (DNMs) in children born to parents employed as cleanup workers or exposed to occupational and environmental ionizing radiation after the accident. Whole-genome sequencing of 130 children (born 1987-2002) and their parents did not reveal an increase in the rates, distributions, or types of DNMs relative to the results of previous studies. We find no elevation in total DNMs, regardless of cumulative preconception gonadal paternal [mean = 365 milligrays (mGy), range = 0 to 4080 mGy] or maternal (mean = 19 mGy, range = 0 to 550 mGy) exposure to ionizing radiation. Thus, we conclude that, over this exposure range, evidence is lacking for a substantial effect on germline DNMs in humans, suggesting minimal impact from transgenerational genetic effects.

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External Sources

  1. View Full Text
  2. DOI: 10.1126/science.abg2365
  3. PMID: 33888597
  4. View record in Web of Science®
  5. WOS: 000651125300047

Library Notes

  1. Fiscal Year: FY2020-2021
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