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Rapid pathogen-specific recruitment of immune effector cells in the skin by secreted toxins

  1. Author:
    Nguyen, Thuan H.
    Cheung, Gordon Y. C.
    Rigby, Kevin M.
    Kamenyeva, Olena
    Kabat, Juraj
    Sturdevant, Daniel E.
    Villaruz, Amer E.
    Liu, Ryan
    Piewngam, Pipat
    Porter, Adeline R.
    Firdous, Saba
    Chiou, Janice
    Park, Matthew D.
    Hunt, Rachelle L.
    Almufarriji, Fawaz M. F.
    Tan, Vee Y.
    Asiamah, Titus K.
    McCausland, Joshua W.
    Fisher, Emilie L.
    Yeh, Anthony J.
    Bae, Justin S.
    Kobayashi, Scott D.
    Wang,Jiming
    Barber, Daniel L.
    DeLeo, Frank R.
    Otto, Michael

  2. Author Address

    NIAID, Pathogen Mol Genet Sect, Lab Bacteriol, NIH, Bethesda, MD 20892 USA.NIAID, Bacteriol Lab, PathogenHost Cell Biol Sect, Rocky Mt Labs,NIH, Hamilton, MT USA.NIAID, Res Technol Branch, Biol Imaging Sect, NIH, Bethesda, MD USA.NIAID, NIH, Res Technol Branch, Rocky Mt Labs,Gen Unit, Hamilton, MT USA.Natl Canc Inst Frederick, Ctr Canc Res, Lab Canc & Immunometabol, Frederick, MD USA.NIAID, T Lymphocyte Biol Unit, Lab Parasit Dis, Natl Inst Hlth, Bethesda, MD USA.Univ Maryland, Sch Med, Baltimore, MD 21201 USA.MiRagen Therapeut Inc, Boulder, CO USA.NIAID, Chlamydia Pathogenesis Sect, Bethesda, MD USA.Cedars Sinai Med Ctr, Grad Sch BioMed Sci, Los Angeles, CA 90048 USA.Icahn Sch Med Mt Sinai, New York, NY 10029 USA.Yale Univ, Microbial Pathogenesis Dept, New Haven, CT USA.Univ Leeds, Sch Mol & Cell Biol, Leeds, England.NIAID, TB Res Sect, Bethesda, MD USA.Johns Hopkins Univ, Baltimore, MD USA.Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA.William Carey Univ Coll Ostepath Med, Hattiesburg, MS USA.Harvard Univ, Cambridge, MA 02138 USA.
    1. Year: 2021
    2. Date: Dec 6
  2. Journal: Nature Microbiology
  3. Nature Portfolio
  5. Type of Article: Article
  6. ISSN: 2058-5276
  1. Abstract:

    Swift recruitment of phagocytic leucocytes is critical in preventing infection when bacteria breach through the protective layers of the skin. According to canonical models, this occurs via an indirect process that is initiated by contact of bacteria with resident skin cells and which is independent of the pathogenic potential of the invader. Here we describe a more rapid mechanism of leucocyte recruitment to the site of intrusion of the important skin pathogen Staphylococcus aureus that is based on direct recognition of specific bacterial toxins, the phenol-soluble modulins (PSMs), by circulating leucocytes. We used a combination of intravital imaging, ear infection and skin abscess models, and in vitro gene expression studies to demonstrate that this early recruitment was dependent on the transcription factor EGR1 and contributed to the prevention of infection. Our findings refine the classical notion of the non-specific and resident cell-dependent character of the innate immune response to bacterial infection by demonstrating a pathogen-specific high-alert mechanism involving direct recruitment of immune effector cells by secreted bacterial products.

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External Sources

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  2. DOI: 10.1038/s41564-021-01012-9
  3. PMID: 34873293
  4. View record in Web of Science®
  5. WOS: 000727128500003

Library Notes

  1. Fiscal Year: FY2021-2022
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