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Molecular Evolution of Severe Acute Respiratory Syndrome Coronavirus 2: Hazardous and More Hazardous Strains Behind the Coronavirus Disease 2019 Pandemic and Their Targeting by Drugs and Vaccines

  1. Author:
    Tuli, Hardeep Singh
    Sak, Katrin
    Aggarwal,Poonam
    Iqubal, Ashif
    Upadhaya, Sushil K.
    Kaur, Jagjit
    Kaur, Ginpreet
    Aggarwal, Diwakar

  2. Author Address

    Maharishi Markandeshwar Deemed Univ, Dept Biotechnol, Mullana, India.Nongovt Org NGO Praeventio, Tartu, Estonia.Natl Canc Inst Frederick, Basic Res Lab, Ctr Canc Res, NIH, Frederick, MD USA.Jamia Hamdard Deemed Univ, Sch Pharmaceut Educ & Res, Dept Pharmacol, Delhi, India.Univ New South Wales, Fac Engn, ARC Ctr Excellence Nanoscale BioPhoton CNBP, Grad Sch Biomed Engn, Sydney, NSW, Australia.Narsee Monjee Inst Management Studies SVKMS NMIMS, Shri Vile Parle Kelavani Mandal, Shobhaben Pratapbhai Patel Sch Pharm & Technol Ma, Mumbai, Maharashtra, India.
    1. Year: 2021
    2. Date: Dec 14
  2. Journal: Frontiers in Cellular and Infection Microbiology
  3. Frontiers Media SA
    1. 11
  5. Type of Article: Article
  6. Article Number: ARTN 763687
  7. ISSN: 2235-2988
  1. Abstract:

    Within almost the last 2 years, the world has been shaken by the coronavirus disease 2019 (COVID-19) pandemic, which has affected the lives of all people. With nearly 4.92 million deaths by October 19, 2021, and serious health damages in millions of people, COVID-19 has been the most serious global challenge after the Second World War. Besides lost lives and long-term health problems, devastating impact on economics, education, and culture will probably leave a lasting impression on the future. Therefore, the actual extent of losses will become obvious only after years. Moreover, despite the availability of different vaccines and vaccination programs, it is still impossible to forecast what the next steps of the virus are or how near we are to the end of the pandemic. In this article, the route of molecular evolution of the coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is thoroughly compiled, highlighting the changes that the virus has undergone during the last 2 years and discussing the approaches that the medical community has undertaken in the fight against virus-induced damages.

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External Sources

  1. View Full Text
  2. DOI: 10.3389/fcimb.2021.763687
  3. View record in Web of Science®
  4. WOS: 000737808900001

Library Notes

  1. Fiscal Year: FY2021-2022
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