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Molecular basis for differing antineurogenic effects of GATA-1a and GATA-1b in Xenopus

  1. Author:
    Chen, H. D.
    Huang, Y. K.
    Ault, K.
    Wong, G. W.
    Lin, M. C. M.
    Chen, H. C.
    Kung, H. F.

  2. Author Address

    Chen HD NICHD, Endocrinol & Reprod Res Branch, NIH Bethesda, MD 20892 USA NICHD, Endocrinol & Reprod Res Branch, NIH Bethesda, MD 20892 USA NCI, Lab Biochem Physiol, Div Basic Sci, FCRDC,NIH Frederick, MD 21702 USA Univ Hong Kong, Inst Mol Biol Hong Kong Hong Kong Peoples R China
    1. Year: 2000
  2. Journal: Biochemical and Biophysical Research Communications
    1. 273
    2. 2
    3. Pages: 614-620
  4. Type of Article: Article
  1. Abstract:

    The erythroid transcription factor GATA-1 in Xenopus has been cloned as a pair of presumably duplicated genes designated as xGATA-1a and xGATA-1b. Although both xGATA-1a and xGATA-1b are able to stimulate erythropoiesis, only xGATA-1b is capable of inhibiting neurogenesis in Xenopus embryos. Chimeras of these two genes were constructed by permuting coding and untranslated regions (UTR) on both ends of these two xGATA-1, and their neurogenesis-inhibitory effects were studied. These results reveal that (1) sequence variations between the coding regions alone do not account for the neurogenesis effect; (2) 3' UTR of xGATA-1a causes the loss of the neurogenesis inhibition of xGATA-1b; (3) 3' UTR of xGATA-1b is essential to inhibit neurogenesis. In addition, the presence of either UTR does not affect the stability of the mRNA in vitro. These observations suggest the influence of 3' UTR in xGATA-1 on the inhibition of neurogenesis. (C) 2000 Academic Press. [References: 21]

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