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Anti-Fibrotic Potential of Tomentosenol A, a Constituent of Cerumen from the Australian Native Stingless Bee, Tetragonula carbonaria

  1. Author:
    Hamilton, Karina D [ORCID]
    Czajkowski, Daniel
    Kong, Nicolas J
    Tran, Trong D [ORCID]
    Gustafson,Kirk [ORCID]
    Pauly,Gary
    Boyle, Glen M [ORCID]
    Simmons, Jacinta L
    Steadman, Robert
    Moseley, Ryan [ORCID]
    Brooks, Peter R [ORCID]
    Ogbourne, Steven M [ORCID]
    Russell, Fraser D [ORCID]

  2. Author Address

    Centre for Bioinnovation, University of the Sunshine Coast, Maroochydore DC, QLD 4558, Australia., School of Health and Behavioural Sciences, University of the Sunshine Coast, Maroochydore DC, QLD 4558, Australia., School of Science, Technology and Engineering, University of the Sunshine Coast, Maroochydore DC, QLD 4558, Australia., Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA., Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA., QIMR Berghofer Medical Research Institute, Locked Bag 2000, PO Royal Brisbane Hospital, Brisbane, QLD 4029, Australia., Wales Kidney Research Unit, School of Medicine, Cardiff Institute of Tissue Engineering and Repair (CITER), Cardiff University, Cardiff CF14 4XN, UK., Regenerative Biology Group, School of Dentistry, Cardiff Institute of Tissue Engineering and Repair (CITER), Cardiff University, Cardiff CF14 4XY, UK.,
    1. Year: 2022
    2. Date: Aug 19
    3. Epub Date: 2022 08 19
  2. Journal: Antioxidants (Basel, Switzerland)
    1. 11
    2. 8
  4. Type of Article: Article
  5. Article Number: 1604
  1. Abstract:

    Bioactivity-guided fractionation was used to isolate two compounds, tomentosenol A (1) and torellianone A (2), from a cerumen extract from Tetragonula carbonaria. The anti-fibrotic activity of these compounds was examined using human cultured neonatal foreskin fibroblasts (NFF) and immortalised keratinocytes (HaCaTs). Tomentosenol A (1), inhibited NFF and HaCaT cell proliferation and prevented NFF and HaCaT scratch wound repopulation at 12.5-25 181;M concentrations. These inhibitory effects were associated with reduced cell viability, determined by tetrazolium dye (MTT) and sulforhodamine B (SRB) assays. Compound 1 further inhibited transforming growth factor-ß1 (TGF-ß1)-stimulated, NFF-myofibroblast differentiation and soluble collagen production; and was an effective scavenger of the model oxidant, 2,2-diphenyl-1-picrylhydrazyl (DPPH 183;), with an EC50 value of 44.7 177; 3.1 181;M. These findings reveal significant anti-fibrotic potential for cerumen-derived tomentosenol A (1).

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External Sources

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  2. DOI: 10.3390/antiox11081604
  3. PMID: 36009323
  4. PMCID: PMC9404848
  5. PII : antiox11081604

Library Notes

  1. Fiscal Year: FY2021-2022
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