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A planar polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia

  1. Author:
    Menin, Luca
    Weber, Janine
    Villa, Stefano
    Martini, Emanuele
    Maspero, Elena
    Niño, Carlos A
    Cancila, Valeria
    Poli, Alessandro
    Maiuri, Paolo
    Palamidessi, Andrea
    Frittoli, Emanuela
    Bianchi, Fabrizio
    Tripodo, Claudio
    Walters,Kylie
    Giavazzi, Fabio
    Scita, Giorgio
    Polo, Simona

  2. Author Address

    IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy., Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Universit 224; degli Studi di Milano, Segrate, Italy., Human Pathology Section, Department of Health Sciences, University of Palermo School of Medicine, Palermo, Italy., Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy., Unit of Cancer Biomarkers, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy; Human Pathology Section, Department of Health Sciences, University of Palermo School of Medicine, Palermo, Italy., Protein Processing Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA., IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy; Dipartimento di Oncologia ed Emato-oncologia, Universit 224; degli Studi di Milano, Milan, Italy. Electronic address: giorgio.scita@ifom.eu., IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy; Dipartimento di Oncologia ed Emato-oncologia, Universit 224; degli Studi di Milano, Milan, Italy. Electronic address: simona.polo@ifom.eu.,
    1. Year: 2023
    2. Date: Aug 16
    3. Epub Date: 2023 08 16
  2. Journal: Cell Reports
    1. 42
    2. 8
    3. Pages: 113001
  4. Type of Article: Article
  5. Article Number: 113001
  1. Abstract:

    Tissue fluidification and collective motility are pivotal in regulating embryonic morphogenesis, wound healing, and tumor metastasis. These processes frequently require that each cell constituent of a tissue coordinates its migration activity and directed motion through the oriented extension of lamellipodium cell protrusions, promoted by RAC1 activity. While the upstream RAC1 regulators in individual migratory cells or leader cells during invasion or wound healing are well characterized, how RAC1 is controlled in follower cells remains unknown. Here, we identify a MYO6-DOCK7 axis essential for spatially restricting RAC1 activity in a planar polarized fashion in model tissue monolayers. The MYO6-DOCK7 axis specifically controls the extension of cryptic lamellipodia required to drive tissue fluidification and cooperative-mode motion in otherwise solid and static carcinoma cell collectives. Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.celrep.2023.113001
  3. PMID: 37590133
  4. PII : S2211-1247(23)01012-4

Library Notes

  1. Fiscal Year: FY2022-2023
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