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Workshop to identify critical windows of exposure for children's health: Cancer work group summary

  1. Author:
    Olshan, A. F.
    Anderson, L.
    Roman, E.
    Fear, N.
    Wolff, M.
    Whyatt, R.
    Vu, V.
    Diwan, B. A.
    Potischman, N.

  2. Author Address

    Olshan AF Univ N Carolina, Sch Publ Hlth, Dept Epidemiol CB 7400 Chapel Hill, NC 27599 USA Univ N Carolina, Sch Publ Hlth, Dept Epidemiol Chapel Hill, NC 27599 USA NCI, Comparat Carcinogenesis Lab Frederick, MD USA Univ Leeds, Inst Epidemiol, Leukaemia Res Fund Leeds W Yorkshire England Mt Sinai Sch Med, Div Environm Hlth Sci New York, NY USA Columbia Univ, Joseph L Mailman Sch Publ Hlth, Div Environm Hlth Sci New York, NY USA US EPA, Natl Ctr Environm Assessment Washington, DC 20460 USA Univ Massachusetts, Dept Biostat & Epidemiol Amherst, MA 01003 USA
    1. Year: 2000
  2. Journal: Environmental Health Perspectives
    1. 108
    2. Suppl 3
    3. Pages: 595-597
  4. Type of Article: Article
  1. Abstract:

    We considered whether there are discrete windows of vulnerability in the development of cancer and which time periods may be of the greatest importance. Cancer was considered broadly. including cancers in childhood as well as adult cancers that may have an in utero or childhood origin. We concluded that there was evidence from animal and epidemiologic studies for causal relationships for preconceptional, in utero, and childhood exposures and cancer occurrence in children and adults. However, the evidence is incomplete and all relevant critical windows may not have been identified. The comprehensive evaluation of the relative importance of specific time windows of exposure is limited. Improvements in the design of epidemiologic studies and additional animal studies of mechanisms are warranted. [References: 16]

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