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Associations of tubal ligation and hysterectomy with serum androgen and estrogen metabolites among postmenopausal women in the Women's Health Initiative Observational Study

  1. Author:
    Geczik, Ashley M [ORCID]
    Michels, Kara A
    Anderson, Garnet L
    Falk, Roni T
    Farland, Leslie V
    Manson, JoAnn E
    Shadyab, Aladdin H
    Pfeiffer, Ruth M
    Xu,Xia
    Trabert, Britton

  2. Author Address

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA. ag3895@drexel.edu., Department of Environmental and Occupational Health, Dornsife School of Public Health, Drexel University, Philadelphia, PA, 19104, USA. ag3895@drexel.edu., Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA., Department of Medicine, Brigham and Women 39;s Hospital and Harvard Medical School, Boston, MA, USA., Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Herbert Wertheim School of Public Health and Human Longevity Science, University of California - San Diego, La Jolla, CA, USA., Cancer Research Technology Program, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Department of Obstetrics and Gynecology, University of Utah, Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT, USA.,
    1. Year: 2024
    2. Date: May 21
    3. Epub Date: 2024 05 21
  2. Journal: Cancer Causes & Control : CCC
  4. Type of Article: Article
  1. Abstract:

    Hysterectomy is associated with subsequent changes in circulating hormone levels, but the evidence of an association for tubal ligation is unclear. We evaluated whether circulating concentrations of androgens and estrogens differ by tubal ligation or hysterectomy status in postmenopausal women from the Women's Health Initiative (WHI)-Observational Study (OS). Serum androgens and estrogens were measured in 920 postmenopausal women who did not use menopausal hormone therapy at the time of blood draw, of whom 139 self-reported a history of tubal ligation and 102 reported hysterectomy (with intact ovaries). Geometric mean hormone concentrations (GMs) and 95% confidence intervals (CIs) associated with a history of tubal ligation or hysterectomy (ever/never), as well as time since procedures, were estimated using adjusted linear regression with inverse probability of sampling weights to account for selection. Circulating levels of 12 androgen/androgen metabolites and 20 estrogen/estrogen metabolites did not differ by tubal ligation status. Among women reporting prior hysterectomy compared to women without hysterectomy, we observed lower levels of several androgens (e.g., testosterone (nmol/L): GMyes 0.46 [95% CI:0.37-0.57] vs. GMno 0.62 [95% CI:0.53-0.72]) and higher levels of estrogen metabolites, for example, 2-hydroxyestrone-3-methyl ether (GMyes 11.1 [95% CI:8.95-13.9] pmol/L vs. GMno 8.70 [95% CI:7.38-10.3]) and 4-methoxyestrone (GMyes 6.50 [95% CI:5.05-8.37] vs. GMno 4.92 [95% CI:4.00-6.05]). While we did not observe associations between prior tubal ligation and postmenopausal circulating hormone levels, our findings support that prior hysterectomy was associated with lower circulating testosterone levels and higher levels of some estrogen metabolites, which may have implications for future hormone-related disease risks. © 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

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  2. DOI: 10.1007/s10552-024-01882-4
  3. PMID: 38772931
  4. PII : 10.1007/s10552-024-01882-4

Library Notes

  1. Fiscal Year: FY2023-2024
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