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Longitudinal analysis of the lung proteome reveals persistent repair months after mild to moderate COVID-19

  1. Author:
    Kanth, Shreya M
    Huapaya, Julio A
    Gairhe, Salina
    Wang, Honghui
    Tian, Xin
    Demirkale, Cumhur Y
    Hou, Chunyan
    Ma, Junfeng
    Kuhns,Doug
    Fink,Dani
    Malayeri, Ashkan
    Turkbey, Evrim
    Harmon, Stephanie A
    Chen, Marcus Y
    Regenold, David
    Lynch, Nicolas F
    Ramelli, Sabrina
    Li, Willy
    Krack, Janell
    Kuruppu, Janaki
    Lionakis, Michail S
    Strich, Jeffrey R
    Davey, Richard
    Childs, Richard
    Chertow, Daniel S
    Kovacs, Joseph A
    Parizi, Parizad Torabi-
    Suffredini, Anthony F

  2. Author Address

    Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA; Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: shreya.kanth@nih.gov., Office of Biostatistics Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA., Mass Spectrometry and Analytical Pharmacology Shared Resource, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Georgetown University, Washington, DC 20057, USA., Neutrophil Monitoring Lab, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA., Radiology and Imaging Sciences, Clinical Center (CC), National Institutes of Health, Bethesda, MD 20892, USA., Molecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Cardiovascular Branch, National Institute of Heart, Lung, and Blood, National Institutes of Health, Bethesda, MD 20892, USA., Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Pharmacy Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA., Laboratory of Clinical Immunology 160;& Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA., Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA; Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.,
    1. Year: 2024
    2. Date: Jul 16
    3. Epub Date: 2024 06 27
  2. Journal: Cell Reports. Medicine
    1. 5
    2. 7
    3. Pages: 101642
  4. Type of Article: Article
  5. Article Number: 101642
  1. Abstract:

    In order to assess homeostatic mechanisms in the lung after COVID-19, changes in the protein signature of bronchoalveolar lavage from 45 patients with mild to moderate disease at three phases (acute, recovery, and convalescent) are evaluated over a year. During the acute phase, inflamed and uninflamed phenotypes are characterized by the expression of tissue repair and host defense response molecules. With recovery, inflammatory and fibrogenic mediators decline and clinical symptoms abate. However, at 9 months, quantified radiographic abnormalities resolve in the majority of patients, and yet compared to healthy persons, all showed ongoing activation of cellular repair processes and depression of the renin-kallikrein-kinin, coagulation, and complement systems. This dissociation of prolonged reparative processes from symptom and radiographic resolution suggests that occult ongoing disruption of the lung proteome is underrecognized and may be relevant to recovery from other serious viral pneumonias. Published by Elsevier Inc.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.xcrm.2024.101642
  3. PMID: 38981485
  4. PMCID: PMC11293333
  5. View record in Web of Science®
  6. WOS: 001275040900001
  7. PII : S2666-3791(24)00356-2

Library Notes

  1. Fiscal Year: FY2023-2024
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