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Infant feeding and treatment practices could lead to enhanced transmission of Kaposi's sarcoma-associated herpesvirus (KSHV) and other orally shed infections via saliva, in rural south-western Uganda

  1. Author:
    Bukenya, Dominic
    Marshall,Vickie
    Nabaggala, Georgina
    Miley,Wendell
    Mirembe, Miriam
    Whitby,Denise
    Seeley, Janet [ORCID]
    Newton, Robert
    Rochford, Rosemary
    Sabourin, Katherine R

  2. Author Address

    MRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda., Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK., Viral Oncology Section, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, MD, USA., University of York, York, UK., Department of Environmental & Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.,
    1. Year: 2024
    2. Date: Jan
    3. Epub Date: 2024 10 28
  2. Journal: Global Public Health
    1. 19
    2. 1
    3. Pages: 2418594
  4. Type of Article: Article
  5. Article Number: 2418594
  1. Abstract:

    This qualitative sub-study investigated household practices affecting orally shed infections using Kaposi's sarcoma-associated herpesvirus (KSHV) as a focus. Participants enrolled from 50 households in rural south-western Uganda were followed monthly up to three times. At enrolment, in-depth interviews were completed, and venous blood collected. KSHV seropositivity was defined as anti-KSHV antibody detection to any of 25 antigens by multiplex bead-based assay. Mouthwash samples from every visit were tested by qPCR and KSHV shedders defined as individuals with KSHV DNA detected. At least one KSHV seropositive person was in 48/49(98%) households. Among those, 79% had 1+ KSHV shedders including 45% with 1+ always shedders and 92% with 1+ intermittent shedders, not mutually exclusively. All respondents reported feeding infants with pre-masticated hard food/fruits and testing food/tea temperature. Temperature was tested by tasting, pouring tea on their hand, or touching the cup to their cheek. Some cooled food/tea using a utensil or blowing over it. Food sharing amongst children and adults and using the same dish was common practice. To treat colic pain, carers/mothers reported chewing herbs and spitting into the child's mouth. Feeding and treatment practices did not vary by KSHV status. We identified potential KSHV transmission modes in rural Ugandan households.

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External Sources

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  2. DOI: 10.1080/17441692.2024.2418594
  3. PMID: 39467162

Library Notes

  1. Fiscal Year: FY2024-2025
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