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Functional assays for the diagnosis of chronic granulomatous disease

  1. Author:
    Long-Priel,Debra
    Lau,Karen
    Fink,Dani
    Kuhns,Doug

  2. Author Address

    Clinical Services Program, Leidos Biomedical Research, Inc.,Frederick National Laboratory for Cancer Research, Frederick, MD 21702, United States of America., Clinical Services Program, Leidos Biomedical Research, Inc.,Frederick National Laboratory for Cancer Research, Frederick, MD 21702, United States of America. Electronic address: dkuhns@mail.nih.gov.,
    1. Year: 2025
    2. Date: Jan 28
    3. Epub Date: 2025 01 28
  2. Journal: Journal of Immunological Methods
    1. Pages: 113820
  4. Type of Article: Article
  5. Article Number: 113820
  1. Abstract:

    Chronic granulomatous disease (CGD) is a rare immunodeficiency characterized by recurrent bacterial and fungal infections that are attributed to reduced production of reactive oxygen species (ROS) by a multi-component enzyme complex known as the phagocyte NADPH oxidase or NOX2. Presented in this review are descriptions of several assays that assess the production of ROS as well as assays that characterize the expression of specific proteins of NOX2. Copyright © 2025. Published by Elsevier B.V.

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External Sources

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  2. DOI: 10.1016/j.jim.2025.113820
  3. PMID: 39884497
  4. PII : S0022-1759(25)00020-1

Library Notes

  1. Fiscal Year: FY2024-2025
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