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E2F-1 induced apoptosis

  1. Author:
    Phillips, A. C.
    Vousden, K. H.

  2. Author Address

    NCI, Regulat Cell Growth Lab, FCRDC, Bldg 560, Room 22-96, W 7th St, Frederick, MD 21702 USA. NCI, Regulat Cell Growth Lab, FCRDC, Frederick, MD 21702 USA. Vousden KH NCI, Regulat Cell Growth Lab, FCRDC, Bldg 560, Room 22-96, W 7th St, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Apoptosis
    1. 6
    2. 3
    3. Pages: 173-182
  4. Type of Article: Article
  1. Abstract:

    Members of the E2F family of transcription factors play an important role in regulating the cell cycle, and their activity is often perturbed during the development of human malignancies. More recent work has shown that E2F-1 regulates apoptosis as well as proliferation, in part by stabilizing the p53 tumor suppressor, an important mediator of apoptosis. This has led to the suggestion that E2F-1 may function as a tumor surveillance mechanism, detecting aberrant proliferation and engaging apoptotic pathways to protect the organism from developing tumors.

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