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Regulation and function of the p53 tumor suppressor protein

  1. Author:
    Ryan, K. M.
    Phillips, A. C.
    Vousden, K. H.

  2. Author Address

    NCI, Regulat Cell Growth Lab, Bldg 560, Room 22-96, Frederick, MD 21702 USA. NCI, Regulat Cell Growth Lab, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Current Opinion in Cell Biology
    1. 13
    2. 3
    3. Pages: 332-337
  4. Type of Article: Review
  1. Abstract:

    Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant advances have been made recently in our understanding of how p53 function is regulated and the mechanisms by which p53 mediates its effects.

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