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Chemokine receptor gene polymorphisms and risk of human T lymphotropic virus type I infection in Jamaica

  1. Author:
    Hisada, M.
    Lal, R. B.
    Masciotra, S.
    Rudolph, D. L.
    Martin, M. P.
    Carrington, M.
    Wilks, R. J.
    Manns, A.

  2. Author Address

    NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, 6120 Execut B;vd,EPS 8008, Rockville, MD 20852 USA NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD 20852 USA Sci Applicat Int Corp, Frederick Canc Res & Dev Ctr, Intramural Res Support Program, Frederick, MD USA CDCP, HIV Immunol & Diagnost Branch, Div AIDS STD & TB Lab Res, Natl Ctr Infect Dis, Atlanta, GA USA Univ W Indies, Res Inst Trop Med, Epidemiol Res Unit, Kingston 7, Jamaica Hisada M NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, 6120 Execut B;vd,EPS 8008, Rockville, MD 20852 USA
    1. Year: 2002
  2. Journal: Journal of Infectious Diseases
    1. 185
    2. 9
    3. Pages: 1351-1354
  4. Type of Article: Article
  1. Abstract:

    Polymorphisms of some chemokine receptor genes and their ligands are associated with susceptibility and progression of human immunodeficiency virus infection. This study assessed whether these variants are also responsible for susceptibility to infection with human T lymphotropic virus (HTLV) type I. Frequencies of CCR5-Delta32, CCR2-64I, and SDF-1-3'A genotype among 116 HTLV-I-positive and 126 HTLV-I-negative persons of African descent in Jamaica were 1.0%, 14.9%, and 5.4%, respectively. The association of HTLV-I infection with the most common variant, CCR2-64I, was examined in 532 subjects. Thirteen (5.4%) of 241 HTLV-I-negative subjects were homozygous for CCR2-64I, versus 3 (1.0%) of 291 HTLV-I-positive subjects (P = .005). Among HTLV-I carriers, provirus load and antibody titer were not significantly different in persons with CCR2- +/64I or CCR2-+/+. These findings suggest that CCR2-64I, or alleles in linkage disequilibrium with it, may affect the risk of HTLV-I infection in a recessive manner.

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