Skip NavigationSkip to Content
Return Return to Search Results

Vasocrine formation of tumor cell-lined vascular spaces: Implications for rational design of antiangiogenic therapies

  1. Author:
    Rybak, S. M.
    Sanovich, E.
    Hollingshead, M. G.
    Borgel, S. D.
    Newton, D. L.
    Melillo, G.
    Kong, D. H.
    Kaur, G.
    Sausville, E. A.

  2. Author Address

    NCI, Dev Therapeut Program, Execut Plaza N,Room 8018,6130 Execut Blvd, Rockville, MD 20852 USA NCI, Frederick Canc Res & Dev Ctr, Dev Therapeut Program, Div Canc Treatment & Diag, Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Sci Applicat Int Corp, Frederick, MD 21702 USA Sausville EA NCI, Dev Therapeut Program, Execut Plaza N,Room 8018,6130 Execut Blvd, Rockville, MD 20852 USA
    1. Year: 2003
  2. Journal: Cancer Research
    1. 63
    2. 11
    3. Pages: 2812-2819
  4. Type of Article: Article
  1. Abstract:

    Here we report that B16F10 murine melanoma cells mimic endothelial cell behavior and the angiogenic process in vitro and in vivo. Cord formation in vitro by tumor cells is stimulated by hypoxia and vascular endothelial growth factor (VEGF) and inhibited by antibodies against VEGF and the VEGF KDR receptor (VEGF receptor 2). We define regulation of tumor cell-derived vascular space formation by these vasoactive compounds as "vasocrine" stimulation. ICRF 159 (Razoxane; NSC 129943) prevents tumor cell but not endothelial cell cord formation in vitro, and the antiangiogenic drug TNP-470 (NSC 642492) inhibits endothelial but not tumor cell cord formation in vitro. Both drugs inhibit formation of blood-filled vascular spaces in vivo. These results bear on the anticipated action of ICRF 159 in human clinical trials and novel strategies for targeting tumor blood supplies.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at FrederickClose Button

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel