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Recruitment of HIV and its receptors to dendritic cell-T cell junctions

  1. Author:
    McDonald, D.
    Wu, L.
    Bohks, S. M.
    KewalRamani, V. N.
    Unutmaz, D.
    Hope, T. J.

  2. Author Address

    Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA NCI, HIV Drug Resistance Program, Frederick, MD 21702 USA Vanderbilt Univ, Dept Microbiol & Immunol, Nashville, TN 37232 USA Hope TJ Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA
    1. Year: 2003
  2. Journal: Science
    1. 300
    2. 5623
    3. Pages: 1295-1297
  4. Type of Article: Article
  1. Abstract:

    Monocyte-derived dendritic cells (MDDCs) can efficiently bind and transfer HIV infectivity without themselves becoming infected. Using live-cell microscopy, we found that HIV was recruited to sites of cell contact in MDDCs. Analysis of conjugates between MDDCs and T cells revealed that, in the absence of antigen-specific signaling, the HIV receptors CD4, CCR5, and CXCR4 on the T cell were recruited to the interface while the MDDCs concentrated HIV to the same region. We propose that contact between dendritic cells and T cells facilitates transmission of HIV by locally concentrating virus, receptor, and coreceptor during the formation of an infectious synapse.

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