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Inflammatory Polyarthropathy and Bone Remodeling in Htlv-I Tax-Transgenic Mice

  1. Author:
    Saggioro, D.
    Rosato, A.
    Esposito, G.
    Rosenberg, M. P.
    Harrison, J.
    Felber, B. K.
    Pavlakis, G. N.
    Chiecobianchi, L.

  2. Author Address

    Saggioro D UNIV PADUA IST ONCOL INTERUNIV CTR CANC RES VIA GATTAMELATA 64 I-35128 PADUA ITALY UNIV PADUA IST BIOTECHNOL SECT I-35128 PADUA ITALY GLAXO WELLCOME RES & DEV INST DEPT PHARMACOL RES TRIANGLE PK, NC USA NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM FREDERICK, MD USA
    1. Year: 1997
  2. Journal: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
    1. 14
    2. 3
    3. Pages: 272-280
  4. Type of Article: Article
  1. Abstract:

    Transgenic mice carrying the tax gene of human T-cell lymphotropic virus type I displayed a high prevalence of arthropathy. The percentage of affected animals increased with age, reaching a peak of 43% at 20 months. Southern analysis of deoxyribonucleic acid (DNA) from tissue samples indicated that disease development was related to tax copy number. Histopathologic evaluation of the ankle joints disclosed deep erosion of the synovial lining, fibrous tissue proliferation together with angiogenesis, mononuclear cell infiltration, and activation of osteoclasts. Radiologic examination confirmed joint involvement and revealed bone architecture modifications. The phenotype exhibited by the affected animals closely resembles that of seronegative arthritis in humans, and may indicate tax protein as a causal agent of arthropathy observed in HTLV-I infected individuals. [References: 36]

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