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Novel testis- and embryo-specific isoforms of the phosphofructokinase-1 muscle type gene

  1. Author:
    Yamada, S.
    Nakajima, H.
    Kuehn, M. R.

  2. Author Address

    Kuehn, MR, NCI Frederick, Lab Prot Dynam & Signalling, Canc Res Ctr, Frederick, MD 21702 USA NCI Frederick, Lab Prot Dynam & Signalling, Canc Res Ctr, Frederick, MD 21702 USA. Osaka Med Ctr Canc & Cardiovasc Dis, Dept Clin Lab, Higashinari Ku, Osaka 5378511, Japan.
    1. Year: 2004
  2. Journal: Biochemical and Biophysical Research Communications
    1. 316
    2. 2
    3. Pages: 580-587
  4. Type of Article: Article
  1. Abstract:

    We have identified novel transcriptional isoforms of the human and mouse genes encoding muscle type phosphofructokinase-1 (PFK-M). These isoforms are expressed specifically in the testis and in the mid-gestation embryo, and have been termed TE-PFK-M (testis- and embryo-specific PFK-M). The 5'UTR of TE-PFK-M is composed of three newly identified exons that lie much farther upstream of the PFK-M coding region than the previously characterized 5'UTR. In addition, this upstream region encodes a series of small polyadenylated transcripts, some of which share the same exons found in the 5'UTR of TE-PFK-M, and which may play some role in regulating TE-PFK-M expression. These findings indicate an even more complex level of control of PFK-M expression than previously thought. Published by Elsevier Inc

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