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Differential B cell expression of mouse Fc receptor homologs

  1. Author:
    Davis, R. S.
    Stephan, R. P.
    Chen, C. C.
    Dennis, G.
    Cooper, M. D.

  2. Author Address

    Univ Alabama, Div Dev & Clin Immunol, Birmingham, AL 35294 USA. Univ Alabama, Div Hematol Oncol, Birmingham, AL 35294 USA. Univ Alabama, Dept Med, Birmingham, AL 35294 USA. Univ Alabama, Dept Pediat, Birmingham, AL 35294 USA. Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA. Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA. Howard Hughes Med Inst, Birmingham, AL 35294 USA. Sci Applicat Int Corp, Lab Immunopathogenesis & Bioinformat, Frederick, MD 21702 USA Cooper, MD, Univ Alabama, Div Dev & Clin Immunol, Birmingham, AL 35294 USA
    1. Year: 2004
    2. Date: SEP
  2. Journal: International Immunology
    1. 16
    2. 9
    3. Pages: 1343-1353
  4. Type of Article: Article
  1. Abstract:

    Five Fc receptor homologs (FcRH1-5) possessing inhibitory and/or activating signaling motifs are differentially expressed during B cell differentiation in humans. In this analysis we describe their three mouse orthologs, moFcRH1, moFcRH2 and moFcRH3. The moFcRH genes are located in a chromosome 3 region that is syntenic with the FcRH locus on human chromosome 1. They encode proteins with 2-5 Ig-like domains that share 20-61% extracellular identity with their human counterparts. One moFcRH1 isoform lacks a transmembrane domain as do both moFcRH2 isoforms. The other moFcRH1 isoform and two moFcRH3 isoforms have transmembrane domains and cytoplasmic ITIM and ITAM-like consensus sequences implying their inhibitory or activating signaling potential. Whereas the moFcRH1 and moFcRH3 orthologs are preferentially expressed at different stages in B cell differentiation, the structurally novel moFcRH2 gene is expressed in non-lymphoid tissues. The highly restricted pattern of moFcRH3 expression suggests this member of the phylogenetically conserved FcRH family may have an important immunoregulatory role in marginal zone B cells

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  1. View record in Web of Science®
  2. WOS: 000223826900013

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