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An Information-Intensive Approach to the Molecular Pharmacology of Cancer

  1. Author:
    Weinstein, J. N.
    Myers, T. G.
    Oconnor, P. M.
    Friend, S. H.
    Fornace, A. J.
    Kohn, K. W.
    Fojo, T.
    Bates, S. E.
    Rubinstein, L. V.
    Anderson, N. L.
    Buolamwini, J. K.
    Vanosdol, W. W.
    Monks, A. P.
    Scudiero, D. A.
    Sausville, E. A.
    Zaharevitz, D. W.
    Bunow, B.
    Viswanadhan, V. N.
    Johnson, G. S.
    Wittes, R. E.
    Paull, K. D.

  2. Author Address

    Weinstein JN NCI DIV BASIC SCI MOL PHARMACOL LAB NIH BLDG 37 ROOM 5C-25 9000 ROCKVILLE PIKE BETHESDA, MD 20892 USA FRED HUTCHINSON CANC RES CTR NCI SEATTLE, WA 98105 USA NCI DIV CLIN SCI MED BRANCH NIH BETHESDA, MD 20892 USA NCI DIV CANC TREATMENT DIAGNOSIS & CTR CANC THERAPY EVALUAT PROGRAM BIOMETR RES BRANCH NIH BETHESDA, MD 20892 USA LARGE SCALE BIOL ROCKVILLE, MD 20850 USA NCI FREDERICK CANC RES & DEV CTR SAIC FREDERICK, MD 21701 USA NCI DEV THERAPEUT PROGRAM DCTDC NIH BETHESDA, MD 20892 USA NCI INFORMAT TECHNOL BRANCH DEV THERAPEUT PROGRAM DCTDC NIH BETHESDA, MD 20892 USA NCI GRANTS & CONTRACTS OPERAT BRANCH DEV THERAPEUT PROGRAM DCTDC NIH BETHESDA, MD 20892 USA NCI OFF DIRECTOR DCTDC NIH BETHESDA, MD 20892 USA
    1. Year: 1997
  2. Journal: Science
    1. 275
    2. 5298
    3. Pages: 343-349
  4. Type of Article: Article
  1. Abstract:

    Since 1990, the National Cancer institute (NCI) has screened more than 60,000 compounds against a panel of 60 human cancer cell lines, The 50-percent growth-inhibitory concentration (GI(50)) for any single cell line is simply an index of cytotoxicity or cytostasis, but the patterns of 60 such GI(50) values encode unexpectedly rich, detailed information on mechanisms of drug action and drug resistance. Each compound's pattern is like a fingerprint, essentially unique among the many billions of distinguishable possibilities. These activity patterns are being used in conjunction with molecular structural features of the tested agents to explore the NCI's database of more than 460,000 compounds, and they are providing insight into potential target molecules and modulators of activity in the 60 cell lines, For example, the information is being used to search for candidate anticancer drugs that are not dependent on intact p53 suppressor gene function for their activity. It remains to be seen how effective this information-intensive strategy will be at generating new clinically active agents. [References: 53]

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