Skip NavigationSkip to Content
Return Return to Search Results

Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor

  1. Author:
    Kuhn, J. H.
    Radoshitzky, S. R.
    Guth, A. C.
    Warfield, K. L.
    Li, W. H.
    Vincent, M. J.
    Towner, J. S.
    Nichol, S. T.
    Bavari, S.
    Choe, H.
    Aman, M. J.
    Farzan, M.

  2. Author Address

    Harvard Univ, New England Reg Primate Res Ctr, Sch Med, Dept Microbiol & Mol Genet, Southborough, MA 01772 USA. Free Univ Berlin, Dept Biol, D-14195 Berlin, Germany. USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Special Pathogens Branch, Atlanta, GA 30332 USA. Harvard Univ, Sch Med, Childrens Hosp, Dept Pediat, Boston, MA 02115 USA.;Farzan, M, Harvard Univ, New England Reg Primate Res Ctr, Sch Med, Dept Microbiol & Mol Genet, 1 Pine Hill Dr, Southborough, MA 01772 USA.;farzan@hms.harvard.edu
    1. Year: 2006
    2. Date: Jun
  2. Journal: Journal of Biological Chemistry
    1. 281
    2. 23
    3. Pages: 15951-15958
  4. Type of Article: Article
  5. ISSN: 0021-9258
  1. Abstract:

    The GP(1,2) envelope glycoproteins (GP) of filoviruses (marburg- and ebolaviruses) mediate cell-surface attachment, membrane fusion, and entry into permissive cells. Here we show that a 151-amino acid fragment of the Lake Victoria marburgvirus GP1 subunit bound filovirus-permissive cell lines more efficiently than full-length GP1. An homologous 148-amino acid fragment of the Zaire ebolavirus GP1 subunit similarly bound the same cell lines more efficiently than a series of longer GP1 truncation variants. Neither the marburgvirus GP1 fragment nor that of ebolavirus bound a nonpermissive lymphocyte cell line. Both fragments specifically inhibited replication of infectious Zaire ebolavirus, as well as entry of retroviruses pseudotyped with either Lake Victoria marburgvirus or Zaire ebolavirus GP(1,2). These studies identify the receptor-binding domains of both viruses, indicate that these viruses utilize a common receptor, and suggest that a single small molecule or vaccine can be developed to inhibit infection of all filoviruses.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1074/jbc.M601796200
  3. View record in Web of Science®
  4. WOS: 000237996000046

Library Notes

  1. No notes added.
NCI at FrederickClose Button

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel