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Down-regulation of insulin-like growth factor binding protein-5 (IGFBP-5): Novel marker for cervical carcinogenesis

  1. Author:
    Miyatake, T.
    Ueda, Y.
    Nakashima, R.
    Yoshino, K.
    Kimura, T.
    Murata, T.
    Nomura, T.
    Fujita, M.
    Buzard, G. S.
    Enomoto, T.

  2. Author Address

    Osaka Univ, Dept Obstet & Gynecol, Grad Sch Med, Suita, Osaka 5650871, Japan. Osaka Univ, Dept Radiat Biol & Med Genet, Grad Sch Med, Suita, Osaka 5650871, Japan. Sci Applicat Int Corp, Basic Res Program, Frederick, MD USA.;Enomoto, T, Osaka Univ, Dept Obstet & Gynecol, Grad Sch Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.;enomoto@gyne.med.osaka-u.ac.jp
    1. Year: 2007
    2. Date: May
  2. Journal: International Journal of Cancer
    1. 120
    2. 10
    3. Pages: 2068-2077
  4. Type of Article: Article
  5. ISSN: 0020-7136
  1. Abstract:

    To better understand the underlying pathways of cervical carcinogenesis, cDNA microarray analysis was performed on 2 sets of squamous cell carcinomas (SCCs) and their adjacent normal squamous epitheliums. Consistently altered expression was detected for 32 genes. Real-time RT-PCR analysis was conducted on a selected subset of these genes (S100A2, GPC4, p72, IGFBP-5, TRIM2 and NAB2) for 14 additional SCCs and 10 normal epithelia. This found that, of the 6 candidate genes, only the insulin-like growth factor binding protein-5 (IGFBP-5) mRNA was generally and significantly under-expressed in SCCs (p < 0.001). All normal cervical epithelia (30 of 30) stained positively for IGFBP-5 protein, with 70% showing strong staining, whereas 65% (17/26) of SCC had complete loss of IGFBP-5, and only 8% (2/26) SCC retained strong expression (p < 0.001). Immunohistochemistry of premalignant cervical intraepithelial neoplasia (CIN) lesions shows a significantly weaker or negative staining in advanced CIN3 lesions compared with normal squamous epithelia (p = 0.001). This is the first study to show that down-regulation of IGFBP-5 protein correlates with cervical carcinogenesis and does so at a preneoplastic stage. (c) 2007 Wiley-Liss, Inc.

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External Sources

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  2. DOI: 10.1002/ijc.22264
  3. View record in Web of Science®
  4. WOS: 000245565100002

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