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High production of CXCL13 in blood and brain during persistent infection with the relapsing fever spirochete Borrelia turicatoe

  1. Author:
    Gelderblom, H.
    Londono, D.
    Bai, Y. H.
    Cabral, E. S.
    Quandt, J.
    Hornung, R.
    Martin, R.
    Marques, A.
    Cadavid, D.

  2. Author Address

    Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurol & Neurosci, Newark, NJ USA. Univ Med & Dent New Jersey, New Jersey Med Sch, Ctr Emerging Pathogens, Newark, NJ USA. NIAID, Clin Studies Unit, Lab Clin Infect Dis, Bethesda, MD 20892 USA. NINDS, Cellular Immunol Sect, Neuroimmunol Branch, Bethesda, MD USA. NCI, Clin Serv Program, SAIC Frederick Inc, Frederick, MD 21701 USA.;Cadavid, D, 185 S Orange Ave,MSB H506, Newark, NJ 07103 USA.;cadavidi@umdnj.edu
    1. Year: 2007
    2. Date: Mar
  2. Journal: Journal of Neuropathology and Experimental Neurology
    1. 66
    2. 3
    3. Pages: 208-217
  4. Type of Article: Article
  5. ISSN: 0022-3069
  1. Abstract:

    Relapsing fever (RF) is a multisystemic borrelial infection with frequent neurologic involvement referred to as neuroborreliosis. The absence of an effective antibody response results in persistent infection. To study the consequences to the brain of persistent infection with the RF spirochete Borrelia turicatae, we studied B cell (igh6-/-) and B and T (Rag1-/-) cell-deficient mice inoculated with isogenic serotypes 1 (Bt1) or 2 (Bt2). We foun that Btl was more tissue tropic than Bt2, not only for brain but also for heart. Igh6-/- mice developed more severe clinical disease than Rag1-/- mice. 130-infected brains had widespread microgliosis/brain macrophage activation despite localization of spirochetes in the leptomeninges rather than the brain parenchyma itself. Oligoarray analysis revealed that CXCL13 was the most upregulated gene in the brain of 130-infiected lgh6-/- mice. CXCL13 was also the most abundant of the chemokines we measured in infected blood. Persistent infection did not result in injury to the brain. Treatment with exogenous interleukin-10 reduced microgliosis in the brain and production of CXCL13 in the blood. We concluded that brain involvement in B cell-deficient mice persistently infected with B. turicatae is characterized by prominent microgliosis and production of CXCL13 without detectable injury.

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External Sources

  1. View record in Web of Science®
  2. WOS: 000246852600005

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