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Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations

  1. Author:
    Spierings, E.
    Hendriks, M.
    Absi, L.
    Canossi, A.
    Chhaya, S.
    Crowley, J.
    Dolstra, H.
    Eliaou, J. F.
    Ellis, T.
    Enczmann, J.
    Fasano, M. E.
    Gervais, T.
    Gorodezky, C.
    Kircher, B.
    Laurin, D.
    Leffell, M. S.
    Loiseau, P.
    Malkki, M.
    Markiewicz, M.
    Martinetti, M.
    Maruya, E.
    Mehra, N.
    Oguz, F.
    Oudshoorn, M.
    Pereira, N.
    Rani, R.
    Sergeant, R.
    Thomson, J.
    Tran, T. H.
    Turpeinen, H.
    Yang, K. L.
    Zunec, R.
    Carrington, M.
    de Knijff, P.
    Goulmy, E.

  2. Author Address

    Leiden Univ, Med Ctr, Leiden, Netherlands. EFS Auvergne Loire, Lab Histocompatibil, St Etienne, France. Ist CNR Trapianti Organ Immunocitol, Laquila, Italy. Tata Mem Hosp, Bombay 400012, Maharashtra, India. Natl Blood Ctr, Natl Histocompatibil & Immunogenet Reference Lab, Dublin, Ireland. Radboud Univ Nijmegen, Nijmegen Med Ctr, Cent Hematol Lab, Nijmegen, Netherlands. Hop St Eloi, CHU Montpellier, Unit Immunogenet, Immunol Lab, Montpellier, France. Blood Ctr SE Wisconsin Inc, Milwaukee, WI USA. Univ Hosp, Inst Transplantat Immunol, Dusseldorf, Germany. Az Osped S Giovanni Battista Torino UOADU, Turin, Italy. Catholic Univ Louvain, Clin St Luc, Brussels, Belgium. Inst Diagnost & Reference Epidemiol, Dept Immunol & Immunogenet, Mexico City, DF, Mexico. Innsbruck Med Univ, Div Hematol & Oncol, Innsbruck, Austria. Establissement Francais Sang Rhone Alpes, Lab Immunol Res & Dev, Grenoble, France. Johns Hopkins Univ, Sch Med, Immunogenet Lab, Baltimore, MD 21218 USA. Hop St Louis, Immunol Lab, Paris, France. Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA USA. L Warynski Silesian Med Acad, Hematol & BMT Dept, Katowice, Poland. IRCCS, Policlin San Matteo, Serv Immunoematol & Transfus, Lab HLA, Pavia, Italy. HLA Lab, Sakyo Ku, Kyoto, Japan. All India Inst Med Sci, Dept Transplant Immunol & Immunogenet, New Delhi, India. Istanbul Univ, Istanbul Fac Med, Dept Med Biol, Istanbul, Turkey. Stichting Europdonor, Leiden, Netherlands. Univ Fed Parana, Hosp Clin, Immunogenet Lab, BR-80060000 Curitiba, Parana, Brazil. Natl Inst Immunol, New Delhi 110067, India. Hammersmith Hosp, Clin Immunol Lab, London, England. Univ Cape Town, Sch Med, Lab Tissue Immunol, ZA-7700 Rondebosch, South Africa. Univ Heidelberg, Inst Immunol, Dept Transplantat Immunol, D-6900 Heidelberg, Germany. Finnish Red Cross Blood Serv, Res & Dev, Helsinki, Finland. Tsu Chi Stem Cells Ctr, Cord Blood Bank, Hualien, Taiwan. Clin Hosp Zagreb, Tissue Typing Ctr, Zagreb, Croatia. Sci Applicat Int Corp, Lab Genom Divers, Frederick, MD USA. Frederick Canc Res & Dev, Natl Canc Inst, Frederick, MD USA. Leiden Univ, Med Ctr, Dept Human Genet, Leiden, Netherlands.;Spierings, E, Leiden Univ, Med Ctr, Leiden, Netherlands.;eric.spierings@lumc.nl
    1. Year: 2007
    2. Date: Jun
  2. Journal: Plos Genetics
    1. 3
    2. 6
    3. Pages: 1108-1119
  4. Type of Article: Article
  5. Article Number: e103
  6. ISSN: 1553-7390
  1. Abstract:

    Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft- versus-host disease, and in the curative graft-versus- tumor effect of SCT. The latter characteristic enabled the current application of selected minor H antigens in clinical immunotherapeutic SCT protocols. No information exists on the global phenotypic distribution of the currently identified minor H antigens. Therefore, an estimation of their overall impact in human leukocyte antigen-matched solid organ and SCT in the major ethnic populations is still lacking. For the first time, a worldwide phenotype frequency analysis of ten autosomal minor H antigens was executed by 31 laboratories and comprised 2,685 randomly selected individuals from six major ethnic populations. Significant differences in minor H antigen frequencies were observed between the ethnic populations, some of which appeared to be geographically correlated.

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External Sources

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  2. DOI: 10.1371/journal.pgen.0030103
  3. View record in Web of Science®
  4. WOS: 000248349300023

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