Skip NavigationSkip to Content
Return Return to Search Results

KIR-HLA intercourse in HIV disease

  1. Author:
    Carrington, M.
    Martin, M. P.
    van Bergen, J.

  2. Author Address

    Carrington, Mary, Martin, Maureen P.] NCI, SAIC Frederick Inc, Expt Immunol Lab, Canc & Inflammat Program, Frederick, MD 21702 USA. [van Bergen, Jeroen] Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, Sect Immunochem, NL-2333 ZA Leiden, Netherlands.
    1. Year: 2008
  2. Journal: Trends in Microbiology
    1. 16
    2. 12
    3. Pages: 620-627
  4. Type of Article: Review
  1. Abstract:

    Human leukocyte antigen (HLA) class I loci are essential to an effective immune response against a wide variety of pathogenic microorganisms, and they represent the prototypes for genetic polymorphism that are sustained through balancing selection. The functional significance of HLA class I variation is better exemplified by studies involving HIV type 1 (HIV-1) than any other infectious organism. HLA class I molecules are essential to the acquired immune response, but they are also important in innate immunity as ligands for the killer cell immunoglobulin-like receptors (KIR), which modulate natural killer cell activity. Here we concentrate on the interaction between the HLA-B and KIR3DL1/KIR3DS1 genes, describe the effects of these loci on HIV disease, and discuss questions that remain unresolved.

    See More

  1. Keywords:

External Sources

  1. PMID: 18976921

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel