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Targeting the Activator Protein 1 Transcription Factor for the Prevention of Estrogen Receptor-Negative Mammary Tumors

  1. Author:
    Shen, Q.
    Uray, I. P.
    Li, Y. X.
    Zhang, Y.
    Hill, J.
    Xu, X. C.
    Young, M. R.
    Gunther, E. J.
    Hilsenbeck, S. G.
    Colburn, N. H.
    Chodosh, L. A.
    Brown, P. H.

  2. Author Address

    Shen, Qiang, Uray, Ivan P.; Li, Yuxin, Zhang, Yun, Hill, Jamal, Hilsenbeck, Susan G.; Brown, Powel H.] Baylor Coll Med, Lester & Sue Smith Breast Ctr, Dan L Duncan Canc Ctr, Houston, TX 77030 USA. [Gunther, Edward J.; Chodosh, Lewis A.] Univ Penn, Abramson Family Canc Res Inst, Dept Canc Biol, Philadelphia, PA 19104 USA. [Young, Matthew R.; Colburn, Nancy H.] Natl Canc Inst Frederick, Lab Canc Prevent, Frederick, MD USA. [Xu, Xiao-Chun] Univ Texas MD Anderson Canc Ctr, Dept Clin Canc Prevent, Houston, TX 77030 USA.
    1. Year: 2008
  2. Journal: Cancer Prevention Research
    1. 1
    2. 1
    3. Pages: 45-55
  4. Type of Article: Article
  1. Abstract:

    The oncogene erbB2 is overexpressed in 20% to 30% human breast cancers and is most commonly overexpressed in estrogen receptor (ER)-negative breast cancers. Transgenic mice expressing erbB2 develop ER-negative mammary tumors, mimicking human breast carcinogenesis. Previously, we have shown that activator protein 1 (AP-1) regulates proliferation of

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External Sources

  1. PMID: 19138935

Library Notes

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