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Ceramides: Branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency

  1. Author:
    Kang, J. H.
    Garg, H.
    Sigano, D. M.
    Francella, N.
    Blumenthal, R.
    Marquez, V. E.

  2. Author Address

    Garg, Himanshu, Francella, Nicholas, Blumenthal, Robert] NCI, Nanobiol Program, Ctr Canc Res, NIH, Frederick, MD 21702 USA. [Kang, Ji-Hye, Sigano, Dina M.; Marquez, Victor E.] NCI, Med Chem Lab, NIH, Frederick, MD 21702 USA.
    1. Year: 2009
  2. Journal: Bioorganic & Medicinal Chemistry
    1. 17
    2. 4
    3. Pages: 1498-1505
  4. Type of Article: Article
  1. Abstract:

    The synthesis of a small number of ceramide analogues containing a combination of linear and highly branched alkyl chains on either the D-sphingosine or the N-acyl core of the molecule is reported. Regardless of location, the presence of the branched chain improves potency relative to the positive control, C2 ceramide, however, the most potent compound (4) has the branched side chain as part of the D-sphingosine core. The induction of apoptosis by 4 in terms of Annexin V binding and DiOC(6) labeling was superior to that achieved with C2 ceramide. (c) 2009 Elsevier Ltd. All rights reserved.

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External Sources

  1. PMID: 19171486

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