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Expression of Set, an Inhibitor of Protein Phosphatase 2a, in Renal Development and Wilms-Tumor

  1. Author:
    Carlson, S. G.
    Eng, E.
    Kim, E. C.
    Perlman, E. J.
    Copeland, T. D.
    Ballermann, B. J.

  2. Author Address

    Ballermann BJ JOHNS HOPKINS UNIV SCH MED DEPT MED DIV NEPHROL ROOM 954 ROSS RES BLDG 720 RUTLAND AVE BALTIMORE, MD 21205 USA JOHNS HOPKINS UNIV SCH MED DEPT MED DIV NEPHROL BALTIMORE, MD 21205 USA CHUNGBUK NATL UNIV SCH MED CHEONGJU SOUTH KOREA JOHNS HOPKINS MED INST DEPT PATHOL BALTIMORE, MD 21205 USA NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM FREDERICK, MD USA
    1. Year: 1998
  2. Journal: Journal of the American Society of Nephrology
    1. 9
    2. 10
    3. Pages: 1873-1880
  4. Type of Article: Article
  1. Abstract:

    The human gene set was originally identified as a component of the set-can fusion gene produced by a somatic translocation event in a case of acute undifferentiated leukemia. In the developing kidney, set was highly expressed in the zone of nephron morphogenesis. Recently, SET was shown to be a potent and specific inhibitor of protein phosphatase 2A, a family of major serine/threonine phosphatases involved in regulating cell proliferation and differentiation. The current study sought to define further the role of SET in the regulation of renal cell proliferation and tumorigenesis. The mRNA encoding SET was expressed at much higher levels in transformed human and rodent cell lines than in cultured renal epithelial and primary endothelial cells. Consistent with a role for SET in cell proliferation, set mRNA expression was markedly reduced in cells rendered quiescent by serum starvation, contact inhibition, or differentiation. Previous findings during renal development were extended by demonstrating that SET protein expression is also much greater in developing rat and human kidney than in fully differentiated, mature kidney. Finally, high levels of set mRNA and SET protein expression were found in Wilms' tumor, but not in renal cell carcinoma, adult polycystic kidney disease or in transitional cell carcinoma. [References: 38]

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