Skip NavigationSkip to Content
Return Return to Search Results

Lack of Association Between Excretion of Sorafenib in Sweat and Hand-Foot Skin Reaction

  1. Author:
    Jain, L.
    Gardner, E. R.
    Figg, W. D.
    Chernick, M. S.
    Kong, H. H.

  2. Author Address

    [Jain, Lokesh; Figg, William D.] NIH, Clin Pharmacol Program, Bethesda, MD 20892 USA. [Kong, Heidi H.] NIH, Dermatol Branch, Bethesda, MD 20892 USA. [Chernick, Milica S.] NIDDKD, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Chernick, Milica S.] NIDDKD, Kidney Dis Sect, NIH, Bethesda, MD 20892 USA. [Gardner, Erin R.] NCI, Clin Pharmacol Program, Sci Applicat Int Corp, Frederick, MD 21701 USA.;Kong, HH, NCI, 10 Ctr Dr,Bldg 10,Room 12N238, Bethesda, MD 20892 USA.;konghe@mail.nih.gov
    1. Year: 2010
    2. Date: Jan
  2. Journal: Pharmacotherapy
    1. 30
    2. 1
    3. Pages: 52-56
  4. Type of Article: Article
  5. ISSN: 0277-0008
  1. Abstract:

    Study Objective. To determine if excretion of sorafenib in sweat is associated with hand-foot skin reaction in patients receiving sorafenib. Design. Prospective pilot study. Setting. Outpatient clinic of a cancer research institution. Patients. Two patients who were receiving sorafenib and developed a hand-foot skin reaction of at least grade land two healthy subjects (controls). Intervention. Sweat production was stimulated in both the patients with hand-foot skin reaction and the healthy subjects by means of pilocarpine iontophoresis. Measurements and Main Results. Sweat samples were collected from the patients with hand-foot skin reaction and from the healthy subjects. Using liquid chromatography-tandem mass spectrometry, sorafenib concentrations were measured in the sweat samples. Sweat samples from the healthy subjects were spiked with known concentrations of sorafenib to determine the lower limit of quantification of the assay, which was determined to be 5 ng/ml. Sorafenib concentrations in the samples from the patients with hand-foot skin reaction were undetectable based on the assay's sensitivity. Conclusion. Our results suggest that hand-foot skin reaction in patients receiving sorafenib is not associated with excretion of sorafenib in sweat. Further studies are needed to understand the mechanism of hand-foot skin reaction, a treatment-limiting adverse effect of multikinase inhibitors.

    See More

  1. Keywords:

External Sources

  1. View record in Web of Science®
  2. WOS: 000273471400007

Library Notes

  1. Fiscal Year: FY2009-2010
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel