Skip NavigationSkip to Content
Return Return to Search Results

Two-Step Synthesis of Galactosylated Human Serum Albumin as a Targeted Optical Imaging Agent for Peritoneal Carcinomatosis

  1. Author:
    Regino, C. A. S.
    Ogawa, M.
    Alford, R.
    Wong, K. J.
    Kosaka, N.
    Williams, M.
    Feild, B. J.
    Takahashi, M.
    Choyke, P. L.
    Kobayashi, H.

  2. Author Address

    [Regino, Celeste Aida S.; Ogawa, Mikako; Alford, Raphael; Wong, Karen J.; Kosaka, Noboyuki; Williams, Mark; Choyke, Peter L.; Kobayashi, Hisataka] NCI, Mol Imaging Program, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Alford, Raphael] Case Western Reserve Univ, Sch Med, Cleveland, OH 44106 USA. [Williams, Mark] NCI, Lab Anim Sci Program, SAIC Frederick Inc, Frederick, MD 21702 USA. [Feild, Brian J.; Takahashi, Masatoshi] Shimazdu Sci Instruments, Columbia, MD 21046 USA.;Kobayashi, H, NCI, Mol Imaging Program, Ctr Canc Res, NIH, 10 Ctr Dr,Bldg 10,Room 1B40,MSC 1088, Bethesda, MD 20892 USA.;kobayash@mail.nih.gov
    1. Year: 2010
    2. Date: Feb
  2. Journal: Journal of Medicinal Chemistry
    1. 53
    2. 4
    3. Pages: 1579-1586
  4. Type of Article: Article
  5. ISSN: 0022-2623
  1. Abstract:

    An optical probe, RG-(gal)(28)GSA, was synthesized to improve the detection of peritoneal implants by targeting the beta-D-galactose receptors highly expressed oil the cell surface of a wide variety of cancers arising from the ovary, pancreas, colon, and stomach. Evaluation of RG-(gal)(28)GSA, RG-(gal)(20)GSA, glucose-analogue RG-(glu)(28)GSA, and control RG-HSA demonstrates specificity for the galactose, binding to several human adenocarcinoma cell lines, and cellular internalization. Studies using peritoneally disseminated SHIN3 xenografts in mice also confirmed a preference for galactose with the ability to detect submillimeter size lesions. Preliminary toxicity study for RG-(gal)(28)GSA using Balb/c mice reveal 110 toxic effects up to 100x of the standard imaging dose of 1 mg/kg administered either intraperitoneally or intravenously. These data Indicate that RG-(gal)(28)GSA can selectively target a variety of human adenocarcinomas, can Improve intraoperative or endoscopic tumor detection and resection, and may have little or no toxic in vivo effects hence, it may be clinically translatable.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1021/jm901228u
  3. View record in Web of Science®
  4. WOS: 000274581200014

Library Notes

  1. Fiscal Year: FY2009-2010
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel