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Decreased Prevalence of Lymphatic Filariasis Among Subjects with Type-1 Diabetes

  1. Author:
    Aravindhan, V.
    Mohan, V.
    Surendar, J.
    Rao, M. M.
    Ranjani, H.
    Kumaraswami, V.
    Nutman, T. B.
    Babu, S.

  2. Author Address

    [Aravindhan, Vivekanandhan] Anna Univ, KB Chandrashekar Res Ctr, Lab Mol Immunol, Chennai 600025, Tamil Nadu, India. [Mohan, Vishwanathan; Surendar, Jayagopi; Rao, Maradana Muralidhara] Madras Diabet Res Fdn, Chennai, Tamil Nadu, India. [Kumaraswami, V.; Babu, Subash] Indian Council Med Res, TB Res Ctr, Chennai, Tamil Nadu, India. [Nutman, Thomas B.] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA. [Babu, Subash] Int Ctr Excellence Res, Natl Inst Hlth, Chennai, Tamil Nadu, India. [Babu, Subash] Sci Applicat Int Corp Frederick Inc, Natl Canc Inst Frederick, Frederick, MD USA. [Aravindhan, Vivekanandhan] Anna Univ, KB Chandrashekar Res Ctr Life Sci, Chennai 600025, Tamil Nadu, India.;Aravindhan, V, Anna Univ, KB Chandrashekar Res Ctr, Lab Mol Immunol, Chennai 600025, Tamil Nadu, India.;cvaravindhan@gmail.com drmohans@vsnl.net surendarj85@gmail.com raoinfoster@gmail.com ranjani_h@gmail.com kumaraswamiv@trcchennai.in tnutman@niaid.nih.gov sbabu@mail.nih.gov
    1. Year: 2010
    2. Date: Dec
  2. Journal: American Journal of Tropical Medicine and Hygiene
    1. 83
    2. 6
    3. Pages: 1336-1339
  4. Type of Article: Article
  5. ISSN: 0002-9637
  1. Abstract:

    Several animal studies have shown a protective effect of helminth infections against type-1 diabetes mellitus (T1DM). However, epidemiologic studies demonstrating this protective relationship with T1DM are largely lacking, although an inverse correlation between the prevalence of lymphatic filariasis (LF) and prevalence of allergies and autoimmunity has been shown. A cross-sectional study was undertaken in southern India to assess the baseline prevalence of seropositivity of LF among persons with T1DM (n = 200) and normal glucose tolerant (NGT) persons (n = 562). The prevalence of LF was 0% among persons with T1DM and 2.6% among NGT persons (P = 0.026). The percentage of persons who were positive for filarial antigen-specific IgG4 (but not antigen-specific IgG) was also significantly lower in persons with T1DM (2%) compared with NGT persons (28%) (P < 0.001). Thus, there appears to be a striking inverse relationship between the prevalence of LF and T1DM in southern India.

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External Sources

  1. View Full Text
  2. DOI: 10.4269/ajtmh.2010.10-0410
  3. View record in Web of Science®
  4. WOS: 000285534900030

Library Notes

  1. Fiscal Year: FY2010-2011
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