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Innate immune mechanisms of colitis and colitis-associated colorectal cancer

  1. Author:
    Saleh, M.
    Trinchieri, G.

  2. Author Address

    [Saleh, Maya] McGill Univ, Dept Med, Montreal, PQ H3G 0B1, Canada. [Trinchieri, Giorgio] NCI, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA.;Saleh, M, McGill Univ, Dept Med, Montreal, PQ H3G 0B1, Canada.;maya.saleh@mcgill.ca trinchig@mail.nih.gov
    1. Year: 2011
    2. Date: Jan
  2. Journal: Nature Reviews Immunology
    1. 11
    2. 1
    3. Pages: 9-20
  4. Type of Article: Review
  5. ISSN: 1474-1733
  1. Abstract:

    The innate immune system provides first-line defences in response to invading microorganisms and endogenous danger signals by triggering robust inflammatory and antimicrobial responses. However, innate immune sensing of commensal microorganisms in the intestinal tract does not lead to chronic intestinal inflammation in healthy individuals, reflecting the intricacy of the regulatory mechanisms that tame the inflammatory response in the gut. Recent findings suggest that innate immune responses to commensal microorganisms, although once considered to be harmful, are necessary for intestinal homeostasis and immune tolerance. This Review discusses recent findings that identify a crucial role for innate immune effector molecules in protection against colitis and colitis-associated colorectal cancer and the therapeutic implications that ensue.

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External Sources

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  2. DOI: 10.1038/nri2891
  3. View record in Web of Science®
  4. WOS: 000285572600010

Library Notes

  1. Fiscal Year: FY2010-2011
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