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Evolution of ABC transporters by gene duplication and their role in human disease

  1. Author:
    Moitra, K.
    Dean, M.

  2. Author Address

    [Moitra, Karobi; Dean, Michael] Natl Canc Inst, Expt Immunol Lab, Human Genet Sect, Canc & Inflammat Program, Frederick, MD 21702 USA.;Dean, M, Natl Canc Inst, Expt Immunol Lab, Human Genet Sect, Canc & Inflammat Program, Frederick, MD 21702 USA.;deanm@mail.nih.gov
    1. Year: 2011
    2. Date: Jan
  2. Journal: Biological Chemistry
    1. 392
    2. 1-2
    3. Pages: 29-37
  4. Type of Article: Review
  5. ISSN: 1431-6730
  1. Abstract:

    The ATP-binding cassette (ABC) transporter genes represent the largest family of transporters and these genes are abundant in the genome of all vertebrates. Through analysis of the genome sequence databases we have characterized the full complement of ABC genes from several mammals and other vertebrates. Multiple gene duplication and deletion events were identified in ABC genes in different lineages indicating that the process of gene evolution is still ongoing. Gene duplication resulting in either gene birth or gene death plays a major role in the evolution of the vertebrate ABC genes. The understanding of this mechanism is important in the context of human health because these ABC genes are associated with human disease, involving nearly all organ systems of the body. In addition, ABC genes play an important role in the development of drug resistance in cancer cells. Future genetic, functional, and evolutionary studies of ABC transporters will provide important insight into human and animal biology.

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External Sources

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  2. DOI: 10.1515/bc.2011.006
  3. View record in Web of Science®
  4. WOS: 000286183700005

Library Notes

  1. Fiscal Year: FY2010-2011
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