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Opposing actions of CSW and RasGAP modulate the strength of torso RTK signaling in the Drosophila terminal pathway

  1. Author:
    Cleghon, V.
    Feldmann, P.
    Ghiglione, C.
    Copeland, T. D.
    Perrimon, N.
    Hughes, D. A.
    Morrison, D. K.

  2. Author Address

    Morrison DK NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mol Basis Carcinogenesis Lab Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mol Basis Carcinogenesis Lab Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Special Program Prot Chem Frederick, MD 21702 USA Inst Canc Res, Chester Beatty Labs London SW3 6JB England Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Genet Boston, MA 02115 USA
    1. Year: 1998
  2. Journal: Molecular Cell
    1. 2
    2. 6
    3. Pages: 719-727
  4. Type of Article: Article
  1. Abstract:

    In Drosophila, specification of embryonic terminal cells is controlled by Torso receptor tyrosine kinase. here, we analyze the molecular basis of positive (Y630) and negative (Y918) phosphotyrosine (pY) signaling sites on Torso. We find that the Drosophila homolog of RasGAP associates with pY918 and is a negative effector of Torso signaling. Further, we show that the tyrosine phosphatase Corkscrew (CSW), which associates with pY630 Torso signaling site, thus identifying Torso to be a substrate of CSW in the terminal pathway. CSW also serves as an adaptor protein for DRK binding, physically linking Torso to Ras activation. The opposing actions of CSW and RasGAP modulate the strength of the Torso signal, contributing to the establishment of precise boundaries for terminal structure development. [References: 51]

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