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Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh)

  1. Author:
    Geiman, T. M.
    Durum, S. K.
    Muegge, K.

  2. Author Address

    Muegge K NCI, SAIC, Lab Mol Immunoregulat, Intramural Res Support Program Bldg 560,Room 31-45 Frederick, MD 21702 USA NCI, SAIC, Lab Mol Immunoregulat, Intramural Res Support Program Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Mol Immunoregulat Lab Frederick, MD 21702 USA
    1. Year: 1998
  2. Journal: Genomics
    1. 54
    2. 3
    3. Pages: 477-483
  4. Type of Article: Article
  1. Abstract:

    Hells (Lsh) is a lymphoid-specific presumptive helicase with highest expression in lymphoid precursor cells, Other members of the helicase family participate in maintenance of genome stability, DNA repair, and transcriptional control. Here we report the structure and chromosomal location of the Hells gene. The open reading frame of the murine Hells gene spans at least 26.6 kb of chromosomal DNA and is composed of 18 exons. The genomic structure of the seven helicase domains closely resembles that of mammalian Rad54, a gene whose product appears to be involved in recombination and double-strand break repair. The human homologue, the HELLS gene, has a mRNA expression pattern that is similar to murine Hells expression. Low-stringency hybridization in a Southern analysis reveals homologous Hells genes in a variety of species including Saccharomyces cerevisiae, FISH analysis maps the murine Hells gene to region C3-D1 on chromosome 19, The human homologue maps to a region of synteny on chromosome 10q23-q24, a breakpoint region frequently involved in human leukemia. (C) 1998 Academic Press. [References: 18]

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