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  1. 1.   Effect of North Bicyclo[3.1.0]hexane 2 '-Deoxy-pseudosugars on RNA Interference: A Novel Class of siRNA Modification
  2. Terrazas, M.; Ocampo, S. M.; Perales, J. C.; Marquez, V. E.; Eritja, R.
  3. Chembiochem. 2011, May; 12(7): 1056-1065.
  1. 2.   Evaluation of the effect of pyrimethamine, an anti-malarial drug, on HIV-1 replication
  2. Oguariri, R. M.; Adelsberger, J. W.; Baseler, M. W.; Imamichi, T.
  3. Virus Research. 2010, Nov; 153(2): 269-276.
  1. 3.   Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance
  2. Das, K.; Bandwar, R. P.; White, K. L.; Feng, J. Y.; Sarafianos, S. G.; Tuske, S.; Tu, X. Y.; Clark, A. D.; Boyer, P. L.; Hou, X. R.; Gaffney, B. L.; Jones, R. A.; Miller, M. D.; Hughes, S. H.; Arnold, E.
  3. Journal of Biological Chemistry. 2009 284(50): 35092-35100.
  1. 4.   ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC
  2. Stockwin, L. H.; Yu, S. X.; Stotler, H.; Hollingshead, M. G.; Newton, D. L.
  3. Bmc Cancer. 2009 9(63): 1-13.
  1. 5.   The nucleoside analogs 4 ' C-Methyl thymidine and 4 ' C-Ethyl thymidine block DNA synthesis by wild-type HIV-1 RT and excision proficient NRTI resistant RT variants
  2. Boyer, P. L.; Julias, J. G.; Ambrose, Z.; Siddiqui, M. A.; MarqueZ, V. E.; Hughes, S. H.
  3. Journal of Molecular Biology. 2007, Aug; 371(4): 873-882.
  1. 6.   Nucleosides with self-complementary hydrogen-bonding motifs: Synthesis and base-pairing studies of two nucleosides containing the imidazo 4,5-d pyridazine ring system
  2. Ujjinamatada, R. K.; Paulman, R. L.; Ptak, R. G.; Hosmane, R. S.
  3. Bioorganic & Medicinal Chemistry. 2006, Sep; 14(18): 6359-6367.
  1. 7.   Examining Ty3 polypurine tract structure and function by nucleoside analog interference
  2. Dash, C.; Marino, J. P.; Le Grice, S. F. J.
  3. Journal of Biological Chemistry. 2006, FEB 3; 281(5): 2773-2783.
  1. 8.   Understanding how the herpes thymidine kinase orchestrates optimal sugar and nucleobase conformations to accommodate its substrate at the active site: A chemical approach
  2. Marquez, V. E.; Choi, Y.; Comin, M. J.; Russ, P.; George, C.; Huleihel, M.; Ben-Kasus, T.; Agbaria, R.
  3. Journal of the American Chemical Society. 2005, NOV 2; 127(43): 15145-15150.
  1. 9.   Fixed conformation nucleoside analogs effectively inhibit excision-proficient HIV-1 reverse transcriptases
  2. Boyer, P. L.; Julias, J. G.; Marquez, V. E.; Hughes, S. H.
  3. Journal of Molecular Biology. 2005, JAN 21; 345(3): 441-450.
  1. 10.   Zebularine: A unique molecule for an epigenetically based strategy in cancer chemotherapy. The magic of its chemistry and biology
  2. Marquez, V. E.; Barchi, J. J.; Kelley, J. A.; Rao, K. V. R.; Agbaria, R.; Ben-Kasus, T.; Cheng, J. C.; Yoo, C. B.; Jones, P. A.
  3. Nucleosides Nucleotides & Nucleic Acids. 2005 24(5-7, Sp. Iss.): 305-318.
  1. 11.   A 4 '-C-ethynyl-2 ',3 '-dideoxynucleoside analogue highlights the role of the 3 '-OH in anti-HIV active 4 '-C-ethynyl-2 '-deoxy nucleosides
  2. Siddiqui, M. A.; Hughes, S. H.; Boyer, P. L.; Mitsuya, H.; Van, Q. N.; George, C.; Sarafinanos, S. G.; Marquez, V. E.
  3. Journal of Medicinal Chemistry. 2004, OCT 7; 47(21): 5041-5048.
  1. 12.   Effects of the Delta 67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision
  2. Boyer, P. L.; Imamichi, T.; Sarafianos, S. G.; Arnold, E.; Hughes, S. H.
  3. Journal of Virology. 2004, SEP; 78(18): 9987-9997.
  1. 13.   Infectious transmission and replication of human T-cell leukemia virus type 1
  2. Derse, D.; Heidecker, G.; Mitchell, M.; Hill, S.; Lloyd, P.; Princler, G.
  3. Frontiers in Bioscience. 2004, SEP 1; 9: 2495-2499.
  1. 14.   Fixed conformation nucleoside analogs are effective against excision-proficient HIV-1 RTs
  2. Boyer, P. L.; Marquez, V. E.; Julias, J. G.; Hughes, S. H.
  3. Abstracts of Papers of the American Chemical Society. 2004, AUG 22; 228(Part 1): 167-MEDI, Abstract U937-167-MEDI, Abstract U937.
  1. 15.   Mitochondrial damage and DNA depletion in cord blood and umbilical cord from infants exposed in utero to Combivir
  2. Divi, R. L.; Walker, V. E.; Wade, N. A.; Nagashima, K.; Seilkopf, S. K.; Adams, M. E.; Nesel, C. J.; O'Neill, J. P.; Abrams, E. J.; Poirier, M. C.
  3. Aids. 2004 18(7): 1013-1021.
  1. 16.   Mitochondrial toxicity in fetal Erythrocebus patas monkeys exposed transplacentally to zidovudine plus lamivudine
  2. Gerschenson, M.; Nguyen, V.; Ewings, E. L.; Ceresa, A.; Shaw, J. A.; St Claire, M. C.; Nagashima, K.; Harbaugh, S. W.; Harbaugh, J. W.; Olivero, O. A.; Divi, R. L.; Albert, P. S.; Poirier, M. C.
  3. Aids Research and Human Retroviruses. 2004 20(1): 91-100.
  1. 17.   Mutations at position 184 of human immunodeficiency virus type-1 reverse transcriptase affect virus titer and viral DNA synthesis
  2. Julias, J. G.; Boyer, P. L.; McWilliams, M. J.; Alvord, W. G.; Hughes, S. H.
  3. Virology. 2004 322(1): 13-21.
  1. 18.   Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir
  2. Tuske, S.; Sarafianos, S. G.; Clark, A. D.; Ding, J. P.; Naeger, L. K.; White, K. L.; Miller, M. D.; Gibbs, C. S.; Boyer, P. L.; Clark, P.; Wang, G.; Gaffney, B. L.; Jones, R. A.; Jerina, D. M.; Hughes, S. H.; Arnold, E.
  3. Nature Structural & Molecular Biology. 2004 11(5): 469-474.
  1. 19.   Metabolic pathways of N-methanocarbathymidine, a novel antiviral agent, in native and herpes simplex virus type 1 infected Vero cells
  2. Zalah, L.; Huleihel, M.; Manor, E.; Konson, A.; Ford, H.; Marquez, V. E.; Johns, D. G.; Agbaria, R.
  3. Antiviral Research. 2002 55(1): 63-75.
  1. 20.   Antitumor activity and metabolic activation of N- methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase
  2. Noy, R.; Ben-Zvi, Z.; Manor, E.; Candotti, F.; Morris, J. C.; Ford, H.; Marquez, V. E.; Johns, D. G.; Agbaria, R.
  3. Molecular Cancer Therapeutics. 2002 1(8): 585-593.
  1. 21.   The ribonuclease H activity of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2 is affected by the thumb subdomain of the small protein subunits
  2. Sevilya, Z.; Loya, S.; Hughes, S. H.; Hizi, A.
  3. Journal of Molecular Biology. 2001 311(5): 957-971.
  1. 22.   Relative replication fitness of a high-level 3 '-azido-3 '- deoxythymidine-resistant variant of human immunodeficiency virus type 1 possessing an amino acid deletion at codon 67 and a novel substitution (Thr -> Gly) at codon 69
  2. Imamichi, T.; Berg, S. C.; Imamichi, H.; Lopez, J. C.; Metcalf, J. A.; Falloon, J.; Lane, H. C.
  3. Journal of Virology. 2000 74(23): 10958-10964.
  1. 23.   Genotoxic and functional consequences of transplacental zidovudine exposure in fetal monkey brain mitochondria
  2. Ewings, E. L.; Gerschenson, M.; St Claire, M. C.; Nagashima, K.; Skopets, B.; Harbaugh, S. W.; Harbaugh, J. W.; Poirier, M. C.
  3. Journal of acquired immune deficiency syndromes (1999). 2000 24(2): 100-105.
  1. 24.   Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3 '-azido-3 '-deoxythymidine
  2. Gerschenson, M.; Erhart, S. W.; Paik, C. Y.; Claire, M. C. S.; Nagashima, K.; Skopets, B.; Harbaugh, S. W.; Harbaugh, J. W.; Quan, W.; Poirier, M. C.
  3. Aids Research and Human Retroviruses. 2000 16(7): 635-644.
  1. 25.   Analysis of Hiv-2 Rt Mutants Provides Evidence That Resistance of Hiv-1 Rt and Hiv-2 Rt to Nucleoside Analogs Involves a Repositioning of the Template-Primer
  2. Perach, M.; Rubinek, T.; Hughes, S. H.; Hizi, A.
  3. Journal of Molecular Biology. 1997 268(3): 648-654.
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