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  1. 1.   Deoxybouvardin targets EGFR, MET, and AKT signaling to suppress non-small cell lung cancer cells
  2. Nam, A-Young; Joo, Sang Hoon; Khong,Quan; Park, Jisu; Lee, Na Yeong; Lee, Seung-On; Yoon, Goo; Park, Jin Woo; Na, MinKyun; Shim, Jung-Hyun
  3. Scientific Reports. 2024, Sep 06; 14(1): 20820.
  1. 2.   Vaccination Ameliorates Cellular Inflammatory Responses in SARS-CoV-2 Breakthrough Infections
  2. Huapaya, Julio A; Higgins, Jeanette; Kanth, Shreya; Demirkale, Cumhur; Gairhe, Salina; Aboye, Etsubdink A; Regenold, David; Sahagun, S J; Pastor, Gloria; Swaim, Doris; Dewar,Robin; Rehman,Tauseef; Highbarger,Helene; Lallemand,Perrine; Laverdure,Sylvain; Adelsberger, Joseph; Rupert,Adam; Li, Willy; Krack, Janell; Teferi, Gebeyehu; Kuruppu, Janaki; Strich, Jeffrey R; Davey, Richard; Childs, Richard; Chertow, Daniel; Kovacs, Joseph A; Barnett, Christopher; Torabi-Parizi, Parizad; Suffredini, Anthony F
  3. The Journal of Infectious Diseases. 2023, Feb 18;
  1. 3.   COVID-19 Patient-Reported Symptoms Using FLU-PRO Plus in a Cohort Study: Associations With Infecting Genotype, Vaccine History, and Return to Health
  2. Richard, Stephanie A; Epsi, Nusrat J; Lindholm, David A; Malloy, Allison M W; Maves, Ryan C; Berjohn, Catherine M; Lalani, Tahaniyat; Smith, Alfred G; Mody, Rupal M; Ganesan, Anuradha; Huprikar, Nikhil; Colombo, Rhonda E; Colombo, Christopher J; Madar, Cristian; Jones, Milissa U; Larson, Derek T; Ewers, Evan C; Bazan, Samantha; Fries, Anthony C; Maldonado, Carlos J; Simons, Mark P; Rozman, Julia S; Andronescu, Liana; Mende, Katrin; Tribble, David R; Agan, Brian K; Burgess, Timothy H; Pollett, Simon D; Powers,John
  3. Open Forum Infectious Diseases. 2022, Jul; 9(7): ofac275.
  1. 4.   Inhibition of HSP 90 is associated with potent anti-tumor activity in Papillary Renal Cell Carcinoma
  2. Pahwa, Roma; Dubhashi, Janhavi; Singh, Anand; Jailwala, Parthav; Lobanov,Alexei; Thomas, Craig J; Ceribelli, Michele; Wilson, Kelli; Ricketts, Christopher J; Vocke, Cathy D; Wells, Catherine; Bottaro, Donald P; Linehan, W Marston; Neckers, Len; Srinivasan, Ramaprasad
  3. Journal of Experimental & Clinical Cancer Research : CR. 2022, Jun 27; 41(1): 208.
  1. 5.   The Structural Basis of Akt PH Domain Interaction with Calmodulin
  2. Weako,Jackson; Jang, Hyunbum; Keskin, Ozlem; Nussinov,Ruth; Gursoy, Attila
  3. Biophysical Journal. 2021, May 18; 120(10): 1994-2008.
  1. 6.   Effect of Capivasertib in Patients With an AKT1 E17K-Mutated Tumor NCI-MATCH Subprotocol EAY131-Y Nonrandomized Trial
  2. Kalinsky, Kevin; Hong, Fangxin; McCourt, Carolyn K.; Sachdev, Jasgit C.; Mitchell, Edith P.; Zwiebel, James A.; Doyle, L. Austin; McShane, Lisa M.; Li, Shuli; Gray, Robert J.; Rubinstein, Larry V.; Patton, David; Williams,Mickey; Hamilton, Stanley R.; Conley, Barbara A.; O'Dwyer, Peter J.; Harris, Lyndsay N.; Arteaga, Carlos L.; Chen, Alice P.; Flaherty, Keith T.
  3. JAMA oncology. 2021, Feb 1; 7(2): 271-278.
  1. 7.   Mdm2 phosphorylation by Akt regulates the p53 response to oxidative stress to promote cell proliferation and tumorigenesis
  2. Chibaya, Loretah; Karim,Baktiar; Zhang, Hong; Jones,Stephen
  3. Proceedings of the National Academy of Sciences of the United States of America. 2021, Jan 26; 118(4):
  1. 8.   Patients with NK cell chronic active EBV have immature NK cells and hyperactivation of PI3K/Akt/mTOR and STAT1 pathways
  2. Howe, Matthew K; Dowdell, Kennichi; Kuehn, Hye Sun; Li, Qingxue; Hart, Geoffrey T; Garabedian, Doreen; Liepshutz,Kelly; Hsu, Amy P; Su, Hua; Niemela, Julie E; Stoddard, Jennifer L; Uzel, Gulbu; Shereck, Evan; Schulz, Laura; Feldman, Tatyana; Rosenzweig, Sergio D; Long, Eric O; Dropulic, Lesia; Cohen, Jeffrey I
  3. The Journal of infectious diseases. 2020, OCT 1; 222(7): 1170-1179.
  1. 9.   Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells
  2. McBrien, Julia Bergild; Mavigner, Maud; Franchitti, Lavinia; Smith, S Abigail; White, Erick; Tharp, Gregory K; Walum, Hasse; Busman-Suhay, Kathleen; Aguilera-Sandoval, Christian R; Thayer, William O; Spagnuolo, Rae Ann; Kovarova, Martina; Wahl, Angela; Cervasi, Barbara; Margolis, David M; Vanderford, Thomas H; Carnathan, Diane G; Paiardini, Mirko; Lifson,Jeffrey; Lee, John H; Safrit, Jeffrey T; Bosinger, Steven E; Estes, Jacob D; Derdeyn, Cynthia A; Garcia, J Victor; Kulpa, Deanna A; Chahroudi, Ann; Silvestri, Guido
  3. Nature. 2020, Jan 22;
  1. 10.   Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis
  2. Walia, Vijay; Cuenca,Adrian; Vetter, Melanie; Insinna, Christine; Perera, Sumeth; Lu,Quanlong; Ritt,Daniel; Semler, Elizabeth; Specht,Suzanne; Stauffer,Jimmy; Morrison,Deborah; Lorentzen, Esben; Westlake,Christopher
  3. Developmental cell. 2019, JUL 22; 50(2): 229-+.
  1. 11.   Esophageal squamous cell carcinoma transcriptome reveals the effect of FOXM1 on patient outcome through novel PIK3R3 mediated activation of PI3K signaling pathway
  2. Nicolau-Neto, Pedro; Da Costa, Nathalia Meireles; de Souza Santos, Paulo Thiago; Gonzaga, Isabela Martins; Ferreira, Maria Aparecida; Guaraldi, Simone; Moreira, Miguel Angelo; Seuánez, Hector N; Brewer, Lilian; Bergmann, Anke; Boroni, Mariana; Mencalha, Andre Luiz; Kruel, Cleber Dario Pinto; Lima, Sheila Coelho Soares; Esposito, Dom; Simão, Tatiana Almeida; Pinto, Luis Felipe Ribeiro
  3. Oncotarget. 2018, Mar 30; 9(24): 16634-16647.
  1. 12.   NADPH oxidase 5 (NOX5) - induced reactive oxygen signaling modulates normoxic HIF-1a and p27(Kip1) expression in malignant melanoma and other human tumors
  2. Antony, Smitha; Jiang, Guojian; Wu, Yongzhong; Meitzler, Jennifer L; Makhlouf, Hala R; Haines, Diana; Butcher, Donna; Hoon, Dave S; Ji, Jiuping; Zhang, Yiping; Juhasz, Agnes; Lu, Jiamo; Liu, Han; Dahan, Iris; Konate, Mariam; Roy, Krishnendu K; Doroshow, James H
  3. Molecular Carcinogenesis. 2017, Dec; 56(12): 2643-2662.
  1. 13.   Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras
  2. Bahr, J. C.; Robey, R. W.; Luchenko, V.; Basseville, A.; Chakraborty, A. R.; Kozlowski, H.; Pauly, G. T.; Patel, P.; Schneider, J. P.; Gottesman, M. M.; Bates, S. E.
  3. Oncotarget. 2016, 13-Sep; 7(43): 69804-69815.
  1. 14.   Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells
  2. Hwang, S. K.; Minai-Tehrani, A.; Yu, K. N.; Chang, S. H.; Kim, J. E.; Lee, K. H.; Park, J.; Beck, G. R.; Cho, M. H.
  3. International Journal of Oncology. 2012, May; 40(5): 1515-1524.
  1. 15.   Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy
  2. Logue, J. S.; Morrison, D. K.
  3. Genes & Development. 2012, Apr; 26(7): 641-650.
  1. 16.   MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells
  2. Viola, G.; Bortolozzi, R.; Hamel, E.; Moro, S.; Brun, P.; Castagliuolo, I.; Ferlin, M. G.; Basso, G.
  3. Biochemical Pharmacology. 2012, Jan; 83(1): 16-26.
  1. 17.   Anti-tumor efficacy of naked siRNAs for ERBB3 or AKT2 against lung adenocarcinoma cell xenografts
  2. Sithanandam, G.; Fornwald, L. W.; Fields, J. R.; Morris, N. L.; Anderson, L. M.
  3. International Journal of Cancer. 2012, Jan; 130(2): 251-258.
  1. 18.   The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signalling
  2. Ping, Y. F.; Yao, X. H.; Jiang, J. Y.; Zhao, L. T.; Yu, S. C.; Jiang, T.; Lin, M. C. M.; Chen, J. H.; Wang, B.; Zhang, R.; Cui, Y. H.; Qian, C.; Wang, J. M.; Bian, X. W.
  3. Journal of Pathology. 2011, Jul; 224(3): 344-354.
  1. 19.   Control of proliferation in astrocytoma cells by the receptor tyrosine kinase/PI3K/AKT signaling axis and the use of PI-103 and TCN as potential anti-astrocytoma therapies
  2. Gursel, D. B.; Connell-Albert, Y. S.; Tuskan, R. G.; Anastassiadis, T.; Walrath, J. C.; Hawes, J. J.; Amlin-Van Schaick, J. C.; Reilly, K. M.
  3. Neuro-Oncology. 2011, Jun; 13(6): 610-621.
  1. 20.   Telomerase and primary T cells: biology and immortalization for adoptive immunotherapy
  2. Barsov, E. V.
  3. Immunotherapy. 2011, Mar; 3(3): 407-421.
  1. 21.   The Hypervariable Region of K-Ras4B Is Responsible for Its Specific Interactions with Calmodulin
  2. Abraham, S. J.; Nolet, R. P.; Calvert, R. J.; Anderson, L. M.; Gaponenko, V.
  3. Biochemistry. 2009 48(32): 7575-7583.
  1. 22.   The novel Akt inhibitor Palomid 529 (P529) enhances the effect of radiotherapy in prostate cancer
  2. Diaz, R.; Nguewa, P. A.; Diaz-Gonzalez, J. A.; Hamel, E.; Gonzalez-Moreno, O.; Catena, R.; Serrano, D.; Redrado, M.; Sherris, D.; Calvo, A.
  3. British Journal of Cancer. 2009 100(6): 932-940.
  1. 23.   A model for obesity and gigantism due to disruption of the Ankrd26 gene
  2. Bera, T. K.; Liu, X. F.; Yamada, M.; Gavrilovat, O.; Mezey, E.; Tessarollo, L.; Anver, M.; Hahn, Y.; Lee, B.; Pastan, I.
  3. Proceedings of the National Academy of Sciences of the United States of America. 2008 105(1): 270-275.
  1. 24.   Grb10 and active Raf-1 kinase promote bad-dependent cell survival
  2. Kebache, S.; Ash, J.; Annis, M. G.; Hagan, J.; Huber, M.; Hassard, J.; Stewart, C. L.; Whiteway, M.; Nantel, A.
  3. Journal of Biological Chemistry. 2007, Jul; 282(30): 21873-21883.
  1. 25.   Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors
  2. Granville, C. A.; Warfel, N.; Tsurutani, J.; Hollander, M. C.; Robertson, M.; Fox, S. D.; Veenstra, T. D.; Issaq, H. J.; Linnoila, R. I.; Dennis, P. A.
  3. Clinical Cancer Research. 2007, Apr; 13(7): 2281-2289.
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