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  1. 1.   Development of Grb2 SH2 domain signaling antagonists: A potential new class of antiproliferative agents
  2. Burke, T. R.
  3. International Journal of Peptide Research and Therapeutics. 2006, Mar; 12(1): 33-48.
  1. 2.   Synthesis of a C-terminally biotinylated macrocyclic peptide mimetic exhibiting high Grb2 SH2 domain-binding affinity
  2. Shi, Z. D.; Liu, H. P.; Zhang, M. C.; Worthy, K. M.; Bindu, L.; Yang, D. J.; Fisher, R. J.; Burke, T. R.
  3. Bioorganic & Medicinal Chemistry. 2005, JUL 1; 13(13): 4200-4208.
  1. 3.   Small nonphosphorylated Grb2-SH2 domain antagonists evaluated by surface resonance plasmon technology
  2. Lung, F. D. T.; Chang, C. W.; Chong, M. C.; Liou, C. C.; Li, P.; Peach, M. L.; Nicklaus, M. C.; Lou, B. S.; Roller, P. P.
  3. Peptide Science (Biopolymers). 2005 80(5): 628-635.
  1. 4.   Synthesis of alpha,alpha-disubstituted 4-phosphonophenylalanine analogues as conformationally-constrained phosphotyrosyl mimetics
  2. Oishi, S.; Kang, S. U.; Liu, H. P.; Zhang, M. C.; Yang, D. J.; Deschamps, J. R.; Burke, T. R.
  3. Tetrahedron. 2004 60(13): 2971-2977.
  1. 5.   Macrocyclization in the design of non-phosphorus-containing Grb2 SH2 domain-binding ligands
  2. Shi, Z. D.; Wei, C. Q.; Lee, K. O.; Liu, H. P.; Zhang, M. C.; Araki, T.; Roberts, L. R.; Worthy, K. M.; Fisher, R. J.; Neel, B. G.; Kelley, J. A.; Yang, D. J.; Burke, T. R.
  3. Journal of Medicinal Chemistry. 2004 47(8): 2166-2169.
  1. 6.   Potentiating effect of distant sites in non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain
  2. Long, Y. Q.; Guo, R. B.; Luo, J. H.; Yang, D. J.; Roller, P. P.
  3. Biochemical and Biophysical Research Communications. 2003 310(2): 334-340.
  1. 7.   A novel macrocyclic tetrapeptide mimetic that exhibits low- picomolar Grb2 SH2 domain-binding affinity
  2. Shi, Z. D.; Lee, K.; Liu, H. P.; Zhang, M. C.; Roberts, L. R.; Worthy, K. M.; Fivash, M. J.; Fisher, R. J.; Yang, D. J.; Burke, T. R.
  3. Biochemical and Biophysical Research Communications. 2003 310(2): 378-383.
  1. 8.   Macrocyclization in the design of Grb2 SH2 domain-binding ligands exhibiting high potency in whole-cell systems
  2. Wei, C. Q.; Gao, Y.; Lee, K.; Guo, R.; Li, B. H.; Zhang, M. C.; Yang, D. J.; Burke, T. R.
  3. Journal of Medicinal Chemistry. 2003 46(2): 244-254.
  1. 9.   Utilization of a beta-aminophosphotyrosyl mimetic in the design and synthesis of macrocyclic Grb2 SH2 domain-binding peptides
  2. Lee, K.; Zhang, M. C.; Liu, H. P.; Yang, D. J.; Burke, T. R.
  3. Journal of Medicinal Chemistry. 2003 46(13): 2621-2630.
  1. 10.   Phosphotyrosyl mimetics in the development of signal transduction inhibitors
  2. Burke, T. R.; Lee, K.
  3. Accounts of Chemical Research. 2003 36(6): 426-433.
  1. 11.   Synthesis of N-Fmoc 3-(4-(di-(tert- butyl)phosphonomethyl)phenyl)pipecolic acid as a conformationally constrained phosphotyrosyl mimetic suitably protected for peptide synthesis
  2. Liu, D. G.; Wang, X. Z.; Gao, Y.; Li, B. H.; Yang, D.; Burke, T. R.
  3. Tetrahedron. 2002 58(52): 10423-10428.
  1. 12.   Phosphoryltyrosyl mimetics in the design of peptide-based signal transduction inhibitors
  2. Burke, T. R.; Yao, Z. J.; Liu, D. G.; Voigt, J.; Gao, Y.
  3. Biopolymers. 2001 60(1): 32-44.
  1. 13.   N-terminal carboxyl and tetrazole-containing amides as adjuvants to Grb2 SH2 domain ligand binding
  2. Burke, T. R.; Yao, Z. J.; Gao, Y.; Wu, J. X.; Zhu, X. F.; Luo, J. H.; Guo, R. B.; Yang, D. J.
  3. Bioorganic & Medicinal Chemistry. 2001 9(6): 1439-1445.
  1. 14.   Macrocyclization in the design of a conformationally constrained Grb2 SH2 domain inhibitor
  2. Gao, Y.; Voigt, J.; Wu, J. X.; Yang, D. J.; Burke, T. R.
  3. Bioorganic & Medicinal Chemistry Letters. 2001 11(14): 1889-1892.
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