Comparative Molecular Cytogenetics Core Facility
Aberration Assay/ SCE
Aberration assay or Breakage study is used to detect obvious chromosomal aberrations
such as breaks, gaps, large deletions, dicentrics, chromosomal fragmentations, and
complex rearrangements. This technique is excellent for the preliminary study of
chromosomal instability or aberrations due to radiation or mutagen treatments.
Sister Chromatid Exchange (SCE) is a frequent method of testing for potential DNA
damage. The exchanges are counted and statistically analyzed.