Strain Code 01C40 [CBA/CaHN]
Origin and Characteristics
To N 1973 from Potter at F36+. Strong (1920) from cross of Bagg albino female to
DBA male. Strains C, C3H, C121, and CHI originated from this cross. Sent to Haldane
and Gruenberg from Little in 1932, thence to Carter in 1947, to Harwell in 1954.
Genetics:
A, B, C
Agouti (wild type)
Genes:
Car-2a, Ce-2b, Es-1b, Es-3c, Es-10b,
Gpd-1b, Gpi-1b, Gusb, Hbbd, Idh-1b,
Mod-1b, Mup-1a, Pep-3b, Pgm-1a, Trfa
Hc1, H-2Dk, H-2Kk, Lyb-2b, Tlab.
Diseases
Neoplastic (Spontaneous):
- Mammary tumor frequency moderate. (237)
Non-Neoplastic (Spontaneous)
- Absence of one or more third molars in 18% of males and females. (235)
Non-Neoplastic (Induced):
- Highly susceptible to Edmonston strain of measles virus. (513)
Other Characteristics
Biochemical:
- Acute ethanol administration activated liver tryptophan pyrrolase, and decreased
brain tryptophan metabolism. (028)
Misc:
- Arachidonic acid depressed thymus weight; thymolysis inhibited by indomethacin which
blocks converstion of arachidonic acid into prostaglandins. (456)