Strain Code 01S50 [Cr:NIH(S) (NIH Swiss)]
Origin and Characteristics
Derived from N:GP(S) colony in 1936.
- An N-tropic virus induced from BALB/c embryo fibroblasts (BALB; virus-1) induced
myeloid metaplasia. (341)
- A variant of Citrobacter freundii was identified as the etiologic agent
of transmissible murine colonic hyperplasia. (038)
- Transmissible murine colonic hyperplasia was induced by oral inoculation with
Citrobaxter freundii variant 4280; mortality was low in NIH Swiss mice but
mucosal hyperplasia was greater than in three inbred strains tested. Hyperplasia
was most severe 16 days after inoculation, then regressed; hyperplastic response
appeared to be a defense mechanism of replacing infected mucosal epithelial cells
with newly migrated, uninfected epithelium. (337,037)
- Although no infectious virus was present, NIH Swiss mice consistently and independent
of age were positive for gs antigen (negative for GIX antigen).
- Used extensively for pertussis HSF testing. (088)
- Two murine leukemia virus proteins, p30 and reverse transcriptase found in gravid
uteri throughout gestation; both proteins were most concentrated on first day after
mating, decreased by 90% or more near mid-gestation, and increased greatly by first
day after parturition. (712)
- Infectious leukemia virus has never been detected; iododeoxyuridine induction of
embryo tissue cultures did not yield virus. (607)
- Prototype Fv-1n stock. (410)
- A survey of allozyme poloymorphism at 36 loci indicated strikingly similar gene
structures in NIH Swiss-Webster, CD-1, and a Swiss-Webster colony from Eppley Institute,
and no evidence of random fixation of segregating allozyme alleles. Gpi-1b
was fixed in N:NHI(S); Got-2 (0.97b, 0.03a) and Id-1 (0.97a, 0.03b)
were headed for fixation. (515)
- Carries gene for short ear (se), bent tail (bt), and GPD-1b.
For information regarding audiogenic seizures in Swiss strain mice the reader is
H Misawa, EH Sherr, DJ Lee, DM Chetkovich, A Tan, CE Schreiner, and DS Bredt. 2002.
Identification of a Monogenic Locus (jams1) Causing Juvenile Audiogenic
Seizures in Mice. J Neurosci 22(23):10088–10093.